ReviewEndocrine2016
Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients.
Review in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Observational
- Central hypothyroidism and cardiovascular disease: a Spanish cohort observational study.Hormones (Athens, Greece) · 2026Observational
- Consequences of undertreatment of hypothyroidism.Endocrine · 2024Review
- Risks of suboptimal and excessive thyroid hormone replacement across ages.Journal of endocrinological investigation · 2024Review
- Article
- Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.PloS one · 2022Article
- Vasculometabolic effects in patients with congenital growth hormone deficiency with and without GH replacement therapy during adulthood.Pituitary · 2021Article
- Levothyroxine Therapy in Elderly Patients With Hypothyroidism.Frontiers in endocrinology · 2021Review
- Melatonin on hypothyroidism and gonadal development in rats: a review.JBRA assisted reproduction · 2020Review
- L-T4 Therapy in the Presence of Pharmacological Interferents.Frontiers in endocrinology · 2020Review
- The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.GeroScience · 2019Review
- The diagnosis and management of central hypothyroidism in 2018.Endocrine connections · 2019Review
- Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF-Mediators of inflammation · 2019Article
- Interactions between hypothalamic pituitary thyroid axis and other pituitary dysfunctions.Endocrine · 2018Review
- Less known aspects of central hypothyroidism: Part 2 - Congenital etiologies.Journal of clinical & translational endocrinology · 2018Review
- Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.Journal of clinical & translational endocrinology · 2018Review
- 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism.European thyroid journal · 2018Article
- Chronic exposure to inhaled, traffic-related nitrogen dioxide and a blunted cortisol response in adolescents.Environmental research · 2018Article
- Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism.Endocrine connections · 2018Article
- Central hypothyroidism - a neglected thyroid disorder.Nature reviews. Endocrinology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroidism is characterized by hypometabolism, and may be seen as a part of secondary failure due to pituitary insufficiency or tertiary due to hypothalamic disease. Secondary and tertiary failures are also referred to as central hypothyroidism. Whereas overt primary hypothyroidism has a well-known affection on the heart and cardiovascular system, and may result in cardiac failure, cardiovascular affection is less well recognized in central hypothyroidism. Studies on central hypothyroidism and cardiovascular outcome are few and given the rarity of the diseases often small. Further, there are several limitations given vast difficulties in diagnosing the condition correctly biochemically, and difficulties monitoring the treatment because normal thyroid-pituitary feedback interrelationships are disrupted. The present review summarizes available studies of central adult hypothyroidism and its possible influence on the cardiovascular system, describe differences from primary thyroid failure and seek evidence for performing guidelines for clinical management of this particular thyroid and hypothalamo-pituitary disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.