Evidence map›Paper›PMID 27481304›Full record

ReviewThe American journal of gastroenterology2016

Endoscopic Pancreas Fluid Collection: Methods and Relevance for Clinical Care and Translational Science.

Phil A Hart, Mark Topazian, Massimo Raimondo, Zobeida Cruz-Monserrate, William E Fisher, Gregory B Lesinski, Hanno Steen, Darwin L Conwell

Abstract readReview
In one paragraph

Review in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
    Guideline
  2. Review
  3. Article
  4. Review
  5. Article
  6. Secretin-Enhanced MRCP: How and Why-AJR. American journal of roentgenology · 2021
    Review
  7. Review
  8. Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020
    Article
  9. Observational
  10. Article
  11. Review
  12. Complications of Chronic Pancreatitis.Digestive diseases and sciences · 2017
    Review
  13. Review
  14. Diagnosing Chronic Pancreatitis.Digestive diseases and sciences · 2017
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Phil A HartSection of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Mark TopazianDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Massimo RaimondoDivision of Gastroenterology and Hepatology, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Zobeida Cruz-MonserrateSection of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
William E FisherMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Gregory B LesinskiSection of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Hanno SteenDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Msaachusetts, USA.
Darwin L ConwellSection of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
The Ohio State University Wexner Medical Center · USBaylor College of Medicine · USBoston Children's Hospital · USMayo Clinic · USMayo Clinic in Florida · US

Funding

The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
NIDDK NIH HHS U01 DK108326NIDDK NIH HHS U01 DK108327
6 · The paper itself

Abstract

Pancreatic secretions have an important role in the regulation of a normal nutritional state but can be altered owing to a variety of pathophysiological mechanisms in the context of exocrine pancreatic disease. The development of an endoscopic technique for collection of pancreatic fluid, termed endoscopic pancreatic function testing, has led to improved understanding of these alterations and is particularly helpful to characterize chronic pancreatitis. In addition, investigators have found endoscopically collected pancreatic fluid to be a valuable biofluid for the purposes of translational science. Techniques such as proteomic, cytokine, genetic mutation, DNA methylation, and microRNA analyses, among others, can be utilized to gain a better understanding of the molecular characteristics of chronic pancreatitis and other pancreatic diseases. Endoscopic collection of pancreatic fluid is safe and relatively straightforward, permitting opportunities for longitudinal analysis of these translational markers throughout the course of disease. This manuscript summarizes our current knowledge of pancreatic fluid, with an emphasis on proper techniques for sample collection and handling, its clinical utility, and preliminary observations in translational science.

Indexed as

ProteomicsCytokinesDNA MethylationDNA Mutational AnalysisEndoscopy, Digestive SystemGastrointestinal AgentsHumansMicroRNAsPancreatic DiseasesPancreatic Function TestsPancreatic JuicePancreatitis, ChronicSecretinCytokinesGastrointestinal AgentsMicroRNAsSecretin

Identifiers

PMID27481304
PMCPMC5568003
OpenAlexW2499040884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.