ArticleJournal of biomechanics2016
Changes in sarcomere lengths of the human vastus lateralis muscle with knee flexion measured using in vivo microendoscopy.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Modified surgical anchor refixation in older patients with acute proximal hamstring rupture: clinical outcome, patient satisfaction and muscle strength.Archives of orthopaedic and trauma surgery · 2023Trial
- Subject-specific muscle properties from diffusion tensor imaging significantly improve the accuracy of musculoskeletal models.Journal of anatomy · 2020Trial
- Isometric slow- and fast-contracting skeletal muscle fibres have more similar cellular and molecular properties at 37°C than at 25°C in older adults.The Journal of physiology · 2026Article
- Phosphate and acidosis cause fibre type-specific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults.Experimental physiology · 2026Article
- Effects of Knee Joint Angle on Intramuscular Blood Flow and Muscle Deoxygenation During Fatiguing Isometric Contractions.Scandinavian journal of medicine & science in sports · 2026Article
- Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers.The Journal of general physiology · 2025Article
- Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.American journal of physiology. Cell physiology · 2025Article
- Discussing Conflicting Explanatory Approaches in Flexibility Training Under Consideration of Physiology: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Impact of Starting Knee Flexion Angle on Muscle Activity and Performance during Plyometrics without Jumping.Sensors (Basel, Switzerland) · 2023Article
- Unique morphological architecture of the hamstring muscles and its functional relevance revealed by analysis of isolated muscle specimens and quantification of structural parameters.Journal of anatomy · 2023Article
- Variability ofFrontiers in physiology · 2021Article
- An insight on Drosophila myogenesis and its assessment techniques.Molecular biology reports · 2020Review
- Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles.International journal of molecular sciences · 2020Article
- Muscle alterations induced by electrostimulation are lower at short quadriceps femoris length.European journal of applied physiology · 2020Article
- Acute effect of tendon vibration applied during isometric contraction at two knee angles on maximal knee extension force production.PloS one · 2020Article
- Current Understanding of Residual Force Enhancement: Cross-Bridge Component and Non-Cross-Bridge Component.International journal of molecular sciences · 2019Review
- Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations.PLoS computational biology · 2019Article
- Relationship of muscle morphology to hip displacement in cerebral palsy: a pilot study investigating changes intrinsic to the sarcomere.Journal of orthopaedic surgery and research · 2019Article
- The Mechanical Power of Titin Folding.Cell reports · 2019Article
- In vivo human lower limb muscle architecture dataset obtained using diffusion tensor imaging.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sarcomeres are the basic contractile units of muscle, and their lengths influence muscle force-generating capacity. Despite their importance, in vivo sarcomere lengths remain unknown for many human muscles. Second harmonic generation (SHG) microendoscopy is a minimally invasive technique for imaging sarcomeres in vivo and measuring their lengths. In this study, we used SHG microendoscopy to visualize sarcomeres of the human vastus lateralis, a large knee extensor muscle important for mobility, to examine how sarcomere lengths change with knee flexion and thus affect the muscle׳s force-generating capacity. We acquired in vivo sarcomere images of several muscle fibers of the resting vastus lateralis in six healthy individuals. Mean sarcomere lengths increased (p=0.031) from 2.84±0.16μm at 50° of knee flexion to 3.17±0.13μm at 110° of knee flexion. The standard deviation of sarcomere lengths among different fibers within a muscle was 0.21±0.09μm. Our results suggest that the sarcomeres of the resting vastus lateralis at 50° of knee flexion are near optimal length. At a knee flexion angle of 110° the resting sarcomeres of vastus lateralis are longer than optimal length. These results show a smaller sarcomere length change and greater conservation of force-generating capacity with knee flexion than estimated in previous studies.
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