Evidence map›Paper›PMID 27481047›Full record

ArticleScientific reports2016

Role of the Gut Microbiome in Modulating Arthritis Progression in Mice.

Xiaofei Liu, Benhua Zeng, Juan Zhang, Wenxia Li, Fangxiang Mou, Heng Wang, Qinghua Zou, Bing Zhong, Like Wu, Hong Wei and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322784 (Effects of Dietary Fiber), which is not on this map. Cited by 129 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322784 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Dietary Fiber (Oat Bran) Intervention on Inflammation, Intestinal Flora, Disease Activity and Quality of Life in Patients With Rheumatoid Arthritis

TypeinterventionalSponsorShenzhen People's HospitalRan2022 to 2024Enrolled25ConditionsRheumatoid ArthritisArmsOat bran (dietary fiber)
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 1 synthesis or guideline pooled it.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaofei LiuDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Benhua ZengDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China.
Juan ZhangDepartment of Infectious Diseases, Chongqing Key Laboratory of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China.
Wenxia LiDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China.
Fangxiang MouDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Heng WangDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Qinghua ZouDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Bing ZhongDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Like WuDepartment of Infectious Diseases, Chongqing Key Laboratory of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China.
Hong WeiDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China.
Yongfei FangDepartment of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetics alone cannot explain most cases of rheumatoid arthritis (RA). Thus, investigating environmental factors such as the gut microbiota may provide new insights into the initiation and progression of RA. In this study, we performed 16S rRNA sequencing to characterise the gut microbiota of DBA1 mice that did or did not develop arthritis after induction with collagen. We found that divergence in the distribution of microbiota after induction was pronounced and significant. Mice susceptible to collagen-induced arthritis (CIA) showed enriched operational taxonomic units (OTUs) affiliated with the genus Lactobacillus as the dominant genus prior to arthritis onset. With disease development, the abundance of OTUs affiliated with the families Bacteroidaceae, Lachnospiraceae, and S24-7 increased significantly in CIA-susceptible mice. Notably, germ-free mice conventionalized with the microbiota from CIA-susceptible mice showed a higher frequency of arthritis induction than those conventionalized with the microbiota from CIA-resistant mice. Consistently, the concentration of the cytokine interleukin-17 in serum and the proportions of CD8+T cells and Th17 lymphocytes in the spleen were significantly higher in the former group, whereas the abundances of dendritic cells, B cells, and Treg cells in the spleen were significantly lower. Our results suggest that the gut microbiome influences arthritis susceptibility.

Indexed as

Gastrointestinal MicrobiomeAnimalsArthritis, ExperimentalBacteriaCollagenDisease Models, AnimalDisease ProgressionDNA, BacterialDNA, RibosomalGerm-Free LifeHumansInterleukin-17MiceMice, Inbred DBAPhylogenyRNA, Ribosomal, 16SCollagenDNA, BacterialDNA, RibosomalInterleukin-17RNA, Ribosomal, 16S

Identifiers

PMID27481047
PMCPMC4969881

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.