Evidence map›Paper›PMID 27480987›Full record

Trial reportProgress in orthodontics2016

Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial.

Sombir Singh, Satinder Pal Singh, Ashima Goyal, Ashok Kumar Utreja, Ashok Kumar Jena

2 registry-linked trialsOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Progress in orthodontics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 5 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05733676 narecruitingnot on this mapstarted 2023, after this paper: background citation

Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of AlbertaRan2023 to 2028Enrolled62ConditionsWhite Spot Lesions, Orthodontic Appliance Complication, Caries Arrested, Smooth Surface CariesArmsResin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride
NCT06905379 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled40ConditionsWhite Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Moringa OleiferaArmsMoringa Oleifera, Varnish
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  5. [Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017
    Pooled it
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  11. Antibacterial and physicochemical properties of a zinc oxide nanoparticle-modified orthodontic adhesive : An in vitro study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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  13. Comparative efficacy of ClinproFrontiers in oral health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sombir SinghUnit of Orthodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Satinder Pal SinghUnit of Orthodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ashima GoyalUnit of Pedodontics and Preventive Dentistry, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ashok Kumar UtrejaUnit of Orthodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ashok Kumar JenaDepartment of Dental Surgery, All India Institute of Medical Sciences Sijua, Dumduma, Bhubaneswar, Odisha, India. drashokkjena@gmail.com.
Post Graduate Institute of Medical Education and Research · INAll India Institute of Medical Sciences Bhubaneswar · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne of the most undesirable side effects of comprehensive orthodontic treatment is white spot lesions (WSLs). Despite many attempts at prevention of WSLs, its prevalence remains very high on debonding. There are many agents like fluoride toothpastes, fluoride varnishes, and fluoride mouth rinses, and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is frequently used for the remineralization of WSLs. However, there is no consensus in the literature with respect to the success rates of these agents. Thus, the present study was designed to evaluate the efficacy of fluoride toothpaste alone and in combination with fluoride varnish and CPP-ACP plus crème in the remineralization of post-orthodontic WSLs.

methodsForty-five subjects in the age range of 16-25 years having at least one post-orthodontic WSL were included in the study. All the subjects were randomly divided into three groups (toothpaste group, varnish group, and CPP-ACP group). The efficacy of various remineralizing agents on the remineralization of WSLs was evaluated clinically and by DIAGNOdent immediately after debonding and subsequently after 1, 3, and 6 months of their use.

resultsTwice daily use of fluoride toothpaste alone had no significant effect on remineralization of WSLs at various intervals of observations (P = 0.078). Application of fluoride varnish along with twice daily use of fluoride toothpaste for 6 months significantly decreased the severity of WSLs (P < 0.01). Twice daily use of CPP-ACP plus crème along with fluoride toothpaste had significant effect on remineralization of WSLs at the end of 6 months of observation (P < 0.05). Between the group comparison showed that the mean visual and DIAGNOdent scores at various time intervals of observations were decreased more when fluoride varnish and CPP-ACP crème were used in addition to daily use of fluoride toothpaste, but the differences were not statistically significant (P > 0.05).

conclusionsThe use of fluoride varnish and CPP-ACP plus crème in addition to twice daily use of fluoride toothpaste had no additional benefit in the remineralization of post-orthodontic WSLs.

Indexed as

Tooth RemineralizationAdolescentAdultCariostatic AgentsCaseinsDental CariesDrug CombinationsFemaleFluoridesFluorides, TopicalHumansMaleMaterials TestingMouthwashesPhosphatesRandom AllocationCariostatic Agentscasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsDrug CombinationsFluoridesFluorides, TopicalfluorophosphateMouthwashesPhosphatesToothpastesCPP-ACP crèmeFluoride toothpasteFluoride varnishOrthodonticsWhite spot lesion

Identifiers

PMID27480987
PMCPMC4969265
OpenAlexW2483434389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.