Evidence map›Paper›PMID 27480909›Full record

ArticleJournal of the International Neuropsychological Society : JINS2016

Does Apolipoprotein e4 Status Moderate the Association of Family Environment with Long-Term Child Functioning following Early Moderate to Severe Traumatic Brain Injury? A Preliminary Study.

Amery Treble-Barna, Huaiyu Zang, Nanhua Zhang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Shari L Wade, Brad G Kurowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Brain and behavior · 2017
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amery Treble-Barna1Division of Physical Medicine and Rehabilitation,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.
Huaiyu Zang2Division of Biostatistics and Epidemiology,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.
Nanhua Zhang2Division of Biostatistics and Epidemiology,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.
Lisa J Martin3Division of Human Genetics,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.
Keith Owen Yeates4Deparment of Psychology,Alberta Children's Hospital Research Institute,& Hotchkiss Brain Institute,University of Calgary,Calgary,Alberta,Canada.
H Gerry Taylor5Division of Developmental and Behavioral Pediatrics and Psychology,Department of Pediatrics,Case Western Reserve University and Rainbow Babies and Children's Hospital,University Hospitals Case Medical Center,Cleveland,Ohio.
Shari L Wade1Division of Physical Medicine and Rehabilitation,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.
Brad G Kurowski1Division of Physical Medicine and Rehabilitation,Department of Pediatrics,Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine,Cincinnati,Ohio.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
Long Term Functional Outcomes of Early TBIR01HD042729 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI WADE, SHARI L · 2002 to 2013
$5.2M
Efficacy of Methylphenidate for Management of Long-term Attention Problems inTBIK23HD074683 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI KUROWSKI, BRAD G · 2013 to 2016
$426k
NCATS NIH HHS UL1 TR001425NCRR NIH HHS UL1 RR026314NICHD NIH HHS K12 HD001097NICHD NIH HHS K23 HD074683NICHD NIH HHS L40 HD066480NICHD NIH HHS R01 HD042729
6 · The paper itself

Abstract

objectivesTo examine whether apolipoprotein e4 (APOE) status moderates the association of family environment with child functioning following early traumatic brain injury (TBI).

methodsSixty-five children with moderate to severe TBI and 70 children with orthopedic injury (OI) completed assessments 6, 12, 18 months, and 3.5 and 6.8 years post injury. DNA was extracted from saliva samples and genotyped for APOE e4 status. Linear mixed models examined moderating effects of APOE e4 status on associations between two family environment factors (parenting style, home environment) and three child outcomes (executive functioning, behavioral adjustment, adaptive functioning).

resultsChildren with TBI who were carriers of the e4 allele showed poorer adaptive functioning relative to non-carriers with TBI and children with OI in the context of low authoritarianism. At high levels of authoritarianism, non-carriers with TBI showed the poorest adaptive functioning among groups. There were no main effects or interactions involving APOE and executive functioning or behavioral adjustment.

conclusionsThe APOE e4 allele was detrimental for long-term adaptive functioning in the context of positive parenting, whereas in less optimal parenting contexts, being a non-carrier was detrimental. We provide preliminary evidence for an interaction of APOE e4 status and parenting style in predicting long-term outcomes following early TBI. (JINS, 2016, 22, 859-864).

Indexed as

AuthoritarianismGene-Environment InteractionOutcome Assessment, Health CareAdaptation, PsychologicalApolipoprotein E4Brain Injuries, TraumaticChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleParentingSeverity of Illness IndexApolipoprotein E4Adaptive functionBrain injuriesGene–environment interactionGeneticsNeurobehavioral outcomesParenting style

Identifiers

PMID27480909
PMCPMC5476473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.