Evidence map›Paper›PMID 27480885›Full record

ArticleJournal of magnetic resonance imaging : JMRI2017

MRI with ferumoxytol: A single center experience of safety across the age spectrum.

Kim-Lien Nguyen, Takegawa Yoshida, Fei Han, Ihab Ayad, Brian L Reemtsen, Isidro B Salusky, Gary M Satou, Peng Hu, J Paul Finn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

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  17. High resolution, 3-dimensional Ferumoxytol-enhanced cardiovascular magnetic resonance venography in central venous occlusion.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
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  18. Review
  19. Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kim-Lien NguyenDiagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Takegawa YoshidaDiagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Fei HanDiagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Ihab AyadDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Brian L ReemtsenDivision of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Isidro B SaluskyDepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Gary M SatouDepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Peng HuDiagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
J Paul FinnDiagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Expanding on a new paradigm for MRI in pediatric congenital heart diseaseR01HL127153 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTODOULOU, ANTHONY G, FINN, JOHN PAUL · 2015 to 2024
$6.1M
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL127153
6 · The paper itself

Abstract

purposeTo summarize our single-center safety experience with the off-label use of ferumoxytol for magnetic resonance imaging (MRI) and to compare the effects of ferumoxytol on monitored physiologic indices in patients under anesthesia with those of gadofosveset trisodium. MATERIALS AND

methodsConsecutive patients who underwent ferumoxytol-enhanced (FE) MRI exams were included. Adverse events (AEs) were classified according to the Common Terminology Criteria for Adverse Events v4.0. In a subgroup of patients examined under general anesthesia, recording of blood pressure, heart rate, oxygen saturation, and end-tidal CO

resultsIn all, 217 unique patients, ages 3 days to 94 years, underwent FE-MRI. No ferumoxytol-related severe, life-threatening, or fatal AEs occurred acutely or at follow-up. Two patients developed ferumoxytol-related nausea. Between-group (FE- vs. GE-MRI) comparisons showed no statistical difference in heart rate (P = 0.69, 95% confidence interval [CI] 96-113 bpm), mean arterial blood pressure (MAP) (P = 0.74, 95% CI 44-52 mmHg), oxygen saturation (P = 0.76, 95% CI 94-98%), and end-tidal CO

conclusionIn our single-center experience, no serious AEs occurred with the diagnostic use of ferumoxytol across a wide spectrum of age, renal function, and indications. Because of the limited sample size, firm conclusions cannot be drawn about the generalizability of our results. Thus, vigilance and monitoring are recommended to mitigate potential rare adverse reactions. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:804-812.

Indexed as

Contrast MediaFerrosoferric OxideAdolescentAdultAgedAged, 80 and overAge DistributionChildChild, PreschoolDrug-Related Side Effects and Adverse ReactionsFemaleHumansInfantInfant, NewbornLos AngelesMagnetic Resonance ImagingContrast MediaFerrosoferric Oxidecontrast agentferumoxytolmagnetic resonance angiographymagnetic resonance imagingUSPIO

Identifiers

PMID27480885
PMCPMC5290274
OpenAlexW2493444894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.