Evidence map›Paper›PMID 27480876›Full record

ReviewMolecular and cellular pediatrics2016

Vitamin A-retinoid signaling in pulmonary development and disease.

Hector A Marquez, Wellington V Cardoso

Open access · goldAbstract readReview
In one paragraph

Review in Molecular and cellular pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  10. Article
  11. Review
  12. Lipid Nutrition in Asthma.Cell biochemistry and biophysics · 2021
    Review
  13. Review
  14. Article
  15. Th9 cells in allergic diseases: A role for the microbiota?Scandinavian journal of immunology · 2020
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hector A MarquezPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA. hemarque@bu.edu.
Wellington V CardosoDepartment of Medicine, Columbia Center for Human Development, Columbia University Medical Center, New York, NY, 10032, USA. wvc2104@cumc.columbia.edu.
Boston University · USColumbia University Irving Medical Center · US

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
RETINOIC ACID SIGNALING IN LUNG MORPHOGENESISR01HL067129 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARDOSO, WELLINGTON V. · 2001 to 2015
$4.6M
The role of b-carotene in maternal-fetal nutritionR01HD057493 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI QUADRO, LOREDANA · 2008 to 2013
$1.9M
Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the DevelopinF32HL117529 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MARQUEZ, HECTOR ANTONIO · 2013 to 2013
$39k
NHLBI NIH HHS F32 HL117529NHLBI NIH HHS R01 HL067129NHLBI NIH HHS T32 HL007035NICHD NIH HHS R01 HD057493
6 · The paper itself

Abstract

Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function. These alterations have been linked to disease states including asthma in both human and animal models.

Indexed as

Airway hyperresponsivenessAsthmaDevelopmental pathwaysLung developmentRetinoic acidSmooth muscleVitamin A

Identifiers

PMID27480876
PMCPMC4969253
OpenAlexW2500184948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.