ArticleScientific reports2016
Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed, 174 citations in OpenAlex.
- A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.Advanced healthcare materials · 2026Article
- Methods for a bioengineered 3D human brain-like tissue model of neuroregeneration after traumatic brain injury.Neural regeneration research · 2026Article
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates.Lab on a chip · 2026Article
- Focused ultrasound-induced cavitation in a human brain microphysiological system produces injury signaling biomarkers consistent with blast trauma.npj biomedical innovations · 2026Article
- Molecular resilience of neurons to repetitive mechanical compression.Communications biology · 2026Article
- Engineering Brain Injury In Vitro: Human iPSC-Based Organoids in Microfluidic Systems.Applied sciences (Basel, Switzerland) · 2026Article
- In silico investigation of brain tissue responses associated with mild blast traumatic brain injury.Frontiers in bioengineering and biotechnology · 2026Article
- A Programmable, 3D Neuron-On-Chip Platform Integrating Near Real-Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lipofuscin accumulation in aging and neurodegeneration: a potential "timebomb" overlooked in Alzheimer's disease.Translational neurodegeneration · 2025Review
- A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize withJournal of neurotrauma · 2025Article
- Under-oil neuronal cell culture: Enhanced system stability, yield, and modulated oxygen environment.Journal of neuroscience methods · 2025Article
- A mechanical model for lateral and axial impacts and quantification of effect on viability of SHSY5Y neuroblastoma cells.Scientific reports · 2025Article
- Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Scoping Review.NeuroSci · 2025Article
- Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network.Gels (Basel, Switzerland) · 2025Article
- Cellular mechanisms of traumatic brain injury.npj biological physics and mechanics · 2025Review
- Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures.Frontiers in bioengineering and biotechnology · 2025Review
- Neural Cell Interactions with a Surgical Grade Biomaterial Using a Simulated Injury in Brain Organotypic Slices.Journal of functional biomaterials · 2024Article
- Effect of Human Head Shape on the Risk of Traumatic Brain Injury: A Gaussian Process Regression-Based Machine Learning Approach.Military medicine · 2024Article
- Cortical spheroids show strain-dependent cell viability loss and neurite disruption following sustained compression injury.PloS one · 2024Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the United States over 1.7 million cases of traumatic brain injury are reported yearly, but predictive correlation of cellular injury to impact tissue strain is still lacking, particularly for neuronal injury resulting from compression. Given the prevalence of compressive deformations in most blunt head trauma, this information is critically important for the development of future mitigation and diagnosis strategies. Using a 3D in vitro neuronal compression model, we investigated the role of impact strain and strain rate on neuronal lifetime, viability, and pathomorphology. We find that strain magnitude and rate have profound, yet distinctively different effects on the injury pathology. While strain magnitude affects the time of neuronal death, strain rate influences the pathomorphology and extent of population injury. Cellular injury is not initiated through localized deformation of the cytoskeleton but rather driven by excess strain on the entire cell. Furthermore we find that, mechanoporation, one of the key pathological trigger mechanisms in stretch and shear neuronal injuries, was not observed under compression.
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