Evidence map›Paper›PMID 27480636›Full record

ArticleJournal of microbiology (Seoul, Korea)2016

Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli.

Su-Mi Choi, Jae-Ho Jeong, Hyon E Choy, Minsang Shin

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Su-Mi ChoiDepartment of Microbiology, Chonnam National University Medical School, Gwangju, 61186, Republic of Korea.
Jae-Ho JeongDepartment of Microbiology, Chonnam National University Medical School, Gwangju, 61186, Republic of Korea.
Hyon E ChoyDepartment of Microbiology, Chonnam National University Medical School, Gwangju, 61186, Republic of Korea. hyonchoy@jnu.ac.kr.
Minsang ShinDepartment of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, Republic of Korea. shinms@knu.ac.kr.
Chonnam National University · KRChonnam National University Hospital · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteropathogenic E. coli causes attaching and effacing (A/E) intestinal lesions. The genes involved in the formation of A/E lesions are encoded within a chromosomal island comprising of five major operons, LEE1-5. The global regulator H-NS represses the expression of these operons. Ler, a H-NS homologue, counteracts the H-NS-mediated repression. Using a novel genetic approach, we identified the amino acid residues in Ler that are involved in the interaction with H-NS: I20 and L23 in the C-terminal portion of α-helix 3, and I42 in the following unstructured linker region.

Indexed as

Gene Expression Regulation, BacterialOperonPromoter Regions, GeneticAmino Acid MotifsDown-RegulationEnteropathogenic Escherichia coliEscherichia coli ProteinsPhosphoproteinsTrans-ActivatorsEscherichia coli ProteinsLEE protein, E coliLer protein, E coliPhosphoproteinsTrans-Activatorsenteropathogenic E. coli (EPEC)H-NSLEELertranscription repression

Identifiers

PMID27480636
OpenAlexW2484118815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.