Evidence map›Paper›PMID 27480540›Full record

ReviewJournal of assisted reproduction and genetics2016

What is the contribution of embryo-endometrial asynchrony to implantation failure?

Wan-Tinn Teh, John McBain, Peter Rogers

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05478616 (To Investigate the Expression of Endometrium During Window of Implantation Between Natural Cycles and Artificial Cycles), which is not on this map. Cited by 102 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478616 terminatednot on this mapstarted 2022, after this paper: background citation

To Investigate the Expression of Endometrium During Window of Implantation Between Natural Cycles and Artificial Cycles

TypeobservationalSponsorKaohsiung Veterans General Hospital.Ran2022 to 2023Enrolled3ConditionsUnrecognized Condition
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wan-Tinn TehDepartment of Obstetrics and Gynaecology, University of Melbourne, The Royal Women's Hospital, 20 Flemington Road, Parkville, 3052, VIC, Australia. wantinn.teh@mivf.com.au.
John McBainReproductive Services, The Royal Women's Hospital, Parkville, VIC, Australia.
Peter RogersDepartment of Obstetrics and Gynaecology, University of Melbourne, The Royal Women's Hospital, 20 Flemington Road, Parkville, 3052, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe synchronized development of a viable embryo and a receptive endometrium is critical for successful implantation to take place. The aim of this paper is to review current thinking about the importance of embryo-endometrial synchrony in in vitro fertilization (IVF).

methodsDetailed review of the literature on embryo-endometrial synchrony.

resultsBy convention, the time when the blastocyst first attaches and starts to invade into the endometrium has been defined as the 'window of implantation'. The term window of implantation can be misleading when it is used to imply that there is a single critical window in time that determines whether implantation will be successful or not. Embryo maturation and endometrial development are two independent continuous processes. Implantation occurs when the two tissues fuse and pregnancy is established. A key concept in understanding this event is developmental 'synchrony', defined as when the early embryo and the uterus are both developing at the same rate such that they will be ready to commence and successfully continue implantation at the same time. Many different events, including controlled ovarian hyperstimulation as routinely used in IVF, can potentially disrupt embryo-endometrial synchrony. There is some evidence in humans that implantation rates are significantly reduced when embryo-endometrial development asynchrony is greater than 3 days (±1.5 days).

conclusionsEmbryo-endometrial synchrony is critical for successful implantation. There is an unmet need for improved precision in the evaluation of endometrial development to permit better synchronization of the embryo and the endometrium prior to implantation.

Indexed as

Embryo TransferBlastocystEmbryo ImplantationEmbryonic DevelopmentEndometriumFemaleFertilization in VitroHumansPregnancyUterusEmbryoEndometriumImplantationSynchronyUterine receptivity

Identifiers

PMID27480540
PMCPMC5125144

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.