ArticleScientific reports2016
Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 95 citations in OpenAlex.
- MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy.International journal of pharmaceutics: X · 2025Article
- Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery.Drug delivery and translational research · 2024Article
- Layered Double Hydroxides (LDH) as Delivery Vehicles of a Chimeric Protein Carrying Epitopes from the Porcine Reproductive and Respiratory Syndrome Virus.Pharmaceutics · 2024Article
- Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Layered Double Hydroxides as an Intercalation System for Hydrophobic Molecules.Nanomaterials (Basel, Switzerland) · 2023Article
- Development of DipeptidePharmaceutics · 2023Article
- Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering.Pharmaceutics · 2023Review
- Bio-Inorganic Layered Double Hydroxide Nanohybrids in Photochemotherapy: A Mini Review.International journal of molecular sciences · 2022Review
- Anti-Inflammatory and Analgesic Evaluation of a Phytochemical Intercalated into Layered Double Hydroxide.Pharmaceutics · 2022Article
- Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials.Nanomaterials (Basel, Switzerland) · 2022Article
- Overcoming Antibiotic Resistance: Playing the 'Silver Nanobullet' Card.Materials (Basel, Switzerland) · 2022Article
- Emerging 2D Nanomaterials for Biomedical Applications.Materials today (Kidlington, England) · 2021Article
- Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications.RSC advances · 2021Review
- 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration.Bioactive materials · 2021Article
- Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings.Pharmaceutics · 2020Article
- Sol-Gel Synthesis and Characterization of Coatings of Mg-Al Layered Double Hydroxides.Materials (Basel, Switzerland) · 2019Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule nearby the LDH was noticed for both materials as well any sign of inflammatory reactions. Sidestream Dark Field imaging, used to monitor in real time the microcirculation in tissues, revealed overall integrity of the microcirculatory network neighboring the tablets, with no blood flow obstruction, bleeding and/or increasing of leukocyte endothelial adhesion. After 28 days Mg2Al-Cl promoted multiple collagen invaginations (mostly collagen type-I) among its fragments while Zn2Al-Cl induced predominantly collagen type-III. This work supports previous results in the literature about LDHs compatibility with living matter, endorsing them as functional materials for biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.