Evidence map›Paper›PMID 27480450›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2016

Role of nanoparticle size, shape and surface chemistry in oral drug delivery.

Amrita Banerjee, Jianping Qi, Rohan Gogoi, Jessica Wong, Samir Mitragotri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amrita BanerjeeDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Jianping QiDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA; School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Rohan GogoiCollege of Letters and Science, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Jessica WongDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Samir MitragotriDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA; Center for Bioengineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address: samir@engineering.ucsb.edu.

Funding

Orally bioactive exenatie and insulin for type II diabetesR01DK097379 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MITRAGOTRI, SAMIR S · 2013 to 2016
$1.3M
UC Santa Barbara MARC Program: Bridges to Biomedical Research CareersT34GM113848 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ROTHMAN, JOEL H. · 2015 to 2019
$1.2M
NIDDK NIH HHS R01 DK097379NIGMS NIH HHS T34 GM113848
6 · The paper itself

Abstract

Nanoparticles find intriguing applications in oral drug delivery since they present a large surface area for interactions with the gastrointestinal tract and can be modified in various ways to address the barriers associated with oral delivery. The size, shape and surface chemistry of nanoparticles can greatly impact cellular uptake and efficacy of the treatment. However, the interplay between particle size, shape and surface chemistry has not been well investigated especially for oral drug delivery. To this end, we prepared sphere-, rod- and disc-shaped nanoparticles and conjugated them with targeting ligands to study the influence of size, shape and surface chemistry on their uptake and transport across intestinal cells. A triple co-culture model of intestinal cells was utilized to more closely mimic the intestinal epithelium. Results demonstrated higher cellular uptake of rod-shaped nanoparticles in the co-culture compared to spheres regardless of the presence of active targeting moieties. Transport of nanorods across the intestinal co-culture was also significantly higher than spheres. The findings indicate that nanoparticle-mediated oral drug delivery can be potentially improved with departure from spherical shape which has been traditionally utilized for the design of nanoparticles. We believe that understanding the role of nanoparticle geometry in intestinal uptake and transport will bring forth a paradigm shift in nanoparticle engineering for oral delivery and non-spherical nanoparticles should be further investigated and considered for oral delivery of therapeutic drugs and diagnostic materials.

Indexed as

Caco-2 CellsCell LineCoculture TechniquesDrug CarriersDrug Delivery SystemsHumansIntestinal AbsorptionNanoparticlesParticle SizeSurface PropertiesDrug CarriersNanoparticleOral deliveryShapeSizeSurface chemistryTriple co-culture

Identifiers

PMID27480450
PMCPMC5289391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.