Evidence map›Paper›PMID 27480325›Full record

ReviewInfectious diseases and therapy2016

Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries.

Louis Bont, Paul A Checchia, Brigitte Fauroux, Josep Figueras-Aloy, Paolo Manzoni, Bosco Paes, Eric A F Simões, Xavier Carbonell-Estrany

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Infectious diseases and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04415229 (Seasonality of Respiratory Syncytial Virus), which is not on this map. Cited by 164 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 12 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04415229 completednot on this mapstarted 2019, after this paper: background citation

Seasonality of Respiratory Syncytial Virus (RSV) Bronchiolitis in Children Aged 2 Years or Less Hospitalized in Martinique (French West Indies) a Tropical Area From 2007 to 2018

TypeobservationalSponsorUniversity Hospital Center of MartiniqueRan2019 to 2023Enrolled1,237ConditionsBronchiolitis, Respiratory Syncytial Virus
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 12 syntheses or guidelines pooled it, 288 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 6 countries.

Louis BontUniversity Medical Center Utrecht, Utrecht, The Netherlands.
Paul A ChecchiaBaylor College of Medicine, Texas Children's Hospital Houston, Texas, USA.
Brigitte FaurouxNecker University Hospital and Paris 5 University, Paris, France.
Josep Figueras-AloyHospital Clínic, Catedràtic de Pediatria, Universitat de Barcelona, Barcelona, Spain.
Paolo ManzoniNeonatology and NICU, Sant'Anna Hospital, Turin, Italy.
Bosco PaesDepartment of Pediatrics (Neonatal Division), McMaster University, Hamilton, ON, Canada.
Eric A F SimõesColorado School of Public Health, University of Colorado School of Medicine, Aurora, CO, USA.
Xavier Carbonell-EstranyHospital Clinic, Institut d'Investigacions Biomediques August Pi Suñer (IDIBAPS), Barcelona, Spain. carbonell@comb.cat.
Baylor College of Medicine · USColorado School of Public Health · USConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHôpital Necker-Enfants Malades · FRMcMaster University · CAOspedale Sant'Anna · ITUniversitat de Barcelona · ESUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe REGAL (RSV [respiratory syncytial virus] Evidence-a Geographical Archive of the Literature) series provides a comprehensive review of the published evidence in the field of RSV in Western countries over the last 20 years. This first of seven publications covers the epidemiology and burden of RSV infection.

methodsA systematic review was undertaken for articles published between Jan 1, 1995 and Dec 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov. Studies reporting data for hospital visits/admissions for RSV infection among children (≤18 years of age), as well as studies reporting RSV-associated morbidity, mortality, and risk factors were included. Study quality and strength of evidence (SOE) were graded using recognized criteria.

result2315 studies were identified of which 98 were included. RSV was associated with 12-63% of all acute respiratory infections (ARIs) and 19-81% of all viral ARIs causing hospitalizations in children (high SOE). Annual RSV hospitalization (RSVH) rates increased with decreasing age and varied by a factor of 2-3 across seasons (high SOE). Studies were conflicting on whether the incidence of RSVH has increased, decreased, or remained stable over the last 20 years (moderate SOE). Length of hospital stay ranged from 2 to 11 days, with 2-12% of cases requiring intensive care unit admission (moderate SOE). Case-fatality rates were <0.5% (moderate SOE). Risk factors associated with RSVH included: male sex; age <6 months; birth during the first half of the RSV season; crowding/siblings; and day-care exposure (high SOE).

conclusionRSV infection remains a major burden on Western healthcare systems and has been associated with significant morbidity. Further studies focusing on the epidemiology of RSV infection (particularly in the outpatient setting), the impact of co-infection, better estimates of case-fatality rates and associated risk factors (all currently moderate/low SOE) are needed to determine the true burden of disease.

fundingAbbvie.

Indexed as

Acute respiratory infectionBronchiolitisBurdenEpidemiologyLower respiratory tract infectionRespiratory syncytial virus

Identifiers

PMID27480325
PMCPMC5019979
OpenAlexW2492097794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.