Evidence map›Paper›PMID 27480322›Full record

ArticleTechnology in cancer research & treatment2017

Magnetic Resonance-Guided High-Intensity-Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study.

Michael Chan, Kristopher Dennis, Yuexi Huang, Charles Mougenot, Edward Chow, Carlo DeAngelis, Jennifer Coccagna, Arjun Sahgal, Kullervo Hynynen, Gregory Czarnota and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Interventional Therapies to Treat Cancer Associated Pain.Current treatment options in oncology · 2025
    Review
  5. Article
  6. Review
  7. MR Imaging-Guided Focused Ultrasound for Breast Tumors.Magnetic resonance imaging clinics of North America · 2024
    Review
  8. Review
  9. 3-T magnetic resonance-guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  10. Article
  11. CIRSE Standards of Practice on Thermal Ablation of Bone Tumours.Cardiovascular and interventional radiology · 2022
    Article
  12. Article
  13. Review
  14. Use of percutaneous microwave ablation for the treatment of bone tumors: a retrospective study of clinical outcomes in 47 patients.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019
    Article
  15. Emerging clinical applications of high-intensity focused ultrasound.Diagnostic and interventional radiology (Ankara, Turkey) · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael Chan1 Department of Medical Imaging, University of Toronto, Toronto, Canada.
Kristopher Dennis2 Division of Radiation Oncology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.
Yuexi Huang3 Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Charles Mougenot4 Philips Healthcare, Markham, Ontario, Canada.
Edward Chow5 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Carlo DeAngelis6 Department of Pharmacy, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Jennifer Coccagna5 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Arjun Sahgal5 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Kullervo Hynynen3 Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Gregory Czarnota3 Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
William Chu5 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone is one of the most common sites of metastases, with bone metastases-related pain representing a significant source of morbidity among patients with cancer. Magnetic resonance-guided focused ultrasound is a noninvasive, outpatient modality with the potential for treating painful bone metastases. The aim of this study is to report our initial experience with magnetic resonance-guided focused ultrasound in the treatment of bone metastases and our preliminary analysis of urinary cytokine levels after therapy.

methodsThis was a single-center pilot study of 10 patients with metastatic cancer to investigate the feasibility of magnetic resonance-guided focused ultrasound for primary pain control in device-accessible skeletal metastases. Treatments were performed on a clinical magnetic resonance-guided focused ultrasound system using a volumetric ablation technique. Primary efficacy was assessed using Brief Pain Inventory scores and morphine equivalent daily dose intake at 3 time points: before, day 14, and day 30 after the magnetic resonance-guided focused ultrasound treatment. Urine cytokines were measured 3 days before treatment and 2 days after the treatment.

resultsOf the 10 patients, 8 were followed up 14 days and 6 were followed up 30 days after the treatment. At day 14, 3 patients (37.5%) exhibited partial pain response and 4 patients (50%) exhibited an indeterminate response, and at day 30 after the treatment, 5 patients (83%) exhibited partial pain response. No treatment-related adverse events were recorded. Of the urine cytokines measured, only Transforming growth factor alpha (TGFα) demonstrated an overall decrease, with a trend toward statistical significance ( P = .078).

conclusionOur study corroborates magnetic resonance-guided focused ultrasound as a feasible and safe modality as a primary, palliative treatment for painful bone metastases and contributes to the limited body of literature using magnetic resonance-guided focused ultrasound for this clinical indication.

Indexed as

High-Intensity Focused Ultrasound AblationPain ManagementPalliative CareAdultAgedBone NeoplasmsCancer PainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPilot ProjectsSurgery, Computer-AssistedTomography, X-Ray ComputedTreatment Outcomebone metastasesBrief Pain Inventoryhigh-intensity-focused ultrasoundmagnetic resonance–guided focused ultrasoundmagnetic resonance thermometry

Identifiers

PMID27480322
PMCPMC5665148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.