ArticleTransfusion2016
The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens.
Article in Transfusion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.Transfusion · 2018Trial
- Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens.Scientific reports · 2025Article
- Rh flow cytometry: An updated methodology for D antigen density applied to weak D types 164 and 165.Transfusion · 2023Article
- Transfusion support for a woman withImmunohematology · 2022Article
- Red cell transfusion and alloimmunization in sickle cell disease.Haematologica · 2021Review
- The Significance ofFrontiers in immunology · 2021Article
- Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China.Journal of translational medicine · 2019Article
- A Supplement to TRANSFUSION Abstract Presentations from the AABB Annual Meeting Boston, MA, October 13-16, 2018.Transfusion · 2018Article
- Genotyping in Sickle Cell Disease Patients: The French Strategy.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Review
- Two large deletions extending beyond either end of the RHD gene and their red cell phenotypes.Journal of human genetics · 2018Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundThe Rh system is the most complex and polymorphic blood group system in humans with more than 460 alleles known for the RHD gene. The DAU cluster of RHD alleles is characterized by the single-nucleotide change producing the p.Thr379Met amino acid substitution. It is called the DAU-0 allele and has been postulated to be the primordial allele, from which all other alleles of the DAU cluster have eventually evolved. STUDY DESIGN AND
methodsFor two novel DAU alleles, the nucleotide sequences of all 10 exons as well as adjacent intronic regions, including the 5' and 3' untranslated regions (UTR), were determined for the RHD and RHCE genes. A phylogenetic tree for all DAU alleles was established using the neighbor-joining method with Pan troglodytes as root. Standard hemagglutination and flow cytometry tests were performed.
resultsWe characterized two DAU alleles, DAU-11 and DAU-5.1, closely related to DAU-3 and DAU-5, respectively. A phylogenetic analysis of the 18 known DAU alleles indicated point mutations and interallelic recombination contributing to diversification of the DAU cluster.
conclusionsThe DAU alleles encode a group of RhD protein variants, some forming partial D antigens known to permit anti-D in carriers; all are expected to cause anti-D alloimmunization in recipients of red blood cell transfusions. The DAU alleles evolved through genomic point mutations and recombination. These results suggest that the cluster of DAU alleles represent a clade, which is concordant with our previous postulate that they derived from the primordial DAU-0 allele.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.