ArticleScientific reports2016
Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Meiotic Recombination in Teleosts.Advances in experimental medicine and biology · 2026Review
- Functional Spermatogenesis Across Testicular Developmental Stages in Neomale Large Yellow Croaker (Biology · 2025Article
- The alternative transcription and expression characterization ofFrontiers in genetics · 2023Article
- Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish.Frontiers in genetics · 2023Article
- Functional Modules in Gametogenesis.Frontiers in cell and developmental biology · 2022Article
- Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility.BMC biology · 2021Article
- Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamide.Journal of cellular and molecular medicine · 2021Article
- Identification and Comparison of microRNAs in the Gonad of the Yellowfin Seabream (International journal of molecular sciences · 2020Article
- Chestnut polysaccharides benefit spermatogenesis through improvement in the expression of important genes.Aging · 2020Article
- E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish.PLoS genetics · 2020Article
- Analysis on the Meiosis-Related Gene (Dmc1, Ph1) Expression in Autotriploid Carassius auratus.Marine biotechnology (New York, N.Y.) · 2019Article
- Article
- Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish.Frontiers in cell and developmental biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DMC1 is a recombinase that is essential for meiotic synapsis. Experiments in extensive species of eukaryotes have indicated the independent role of DMC1 in repairing double strand breaks (DSBs) produced during meiosis I. Mutation of dmc1 in mice and human often leads to obstacles in spermatogenesis and male sterility. Here, we report on the disruption of dmc1 in male medaka (Oryzias latipes). Synapsis was disturbed in the mutant medaka testis nuclei, as observed in mice and other organisms. Unexpectedly, the mutant medaka could produce a few sperm and, although most of these had multiple tail or multiple head malformations, some of them could swim, and few of them even had insemination ability. Our transcriptome analysis showed that there was not a remarkable change in the expression of most of the genes involved in the pathways associated with the meiotic DNA repair and flagella assembly. Our results provided an indication of the accessory mechanisms that might be involved in the repair of DSBs during meiosis. In a species besides humans, we provided evidence that disorders in meiosis recombination might lead to the malformation of sperm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.