ArticleHippocampus2016
Repetition suppression in the medial temporal lobe and midbrain is altered by event overlap.
Article in Hippocampus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- The recombined memory: associative inference in Alzheimer's disease.Aging clinical and experimental research · 2023Article
- As within, so without, as above, so below: Common mechanisms can support between- and within-trial category learning dynamics.Psychological review · 2022Article
- Developmental differences in memory reactivation relate to encoding and inference in the human brain.Nature human behaviour · 2022Article
- Interpersonal Family Dynamics Relate to Hippocampal CA Subfield Structure.Frontiers in neuroscience · 2022Article
- Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.Hippocampus · 2021Review
- Disrupted parahippocampal and midbrain function underlie slower verbal learning in adolescent-onset regular cannabis use.Psychopharmacology · 2021Article
- Effect of repetition on the behavioral and neuronal responses to ambiguous Necker cube images.Scientific reports · 2021Article
- EPS mid-career prize 2018: Inference within episodic memory reflects pattern completion.Quarterly journal of experimental psychology (2006) · 2020Article
- Generalization and the hippocampus: More than one story?Neurobiology of learning and memory · 2020Review
- Functional connectivity between memory and reward centers across task and rest track memory sensitivity to reward.Cognitive, affective & behavioral neuroscience · 2019Article
- How do memory systems detect and respond to novelty?Neuroscience letters · 2018Review
- Building concepts one episode at a time: The hippocampus and concept formation.Neuroscience letters · 2018Review
- Effects of Repetition Learning on Associative Recognition Over Time: Role of the Hippocampus and Prefrontal Cortex.Frontiers in human neuroscience · 2018Article
- Modulation of target recollection and recollection rejection networks due to retrieval facilitation and interference.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Repeated encounters with the same event typically lead to decreased activation in the medial temporal lobe (MTL) and dopaminergic midbrain, a phenomenon known as repetition suppression. In contrast, encountering an event that overlaps with prior experience leads to increased response in the same regions. Such increased responding is thought to reflect an associative novelty signal that promotes memory updating to resolve differences between current events and stored memories. Here, we married these ideas to test whether event overlap significantly modulates MTL and midbrain responses-even when events are repeated and expected-to promote memory updating through integration. While undergoing high-resolution functional MRI, participants were repeatedly presented with objects pairs, some of which overlapped with other, intervening pairs and some of which contained elements unique from other pairs. MTL and midbrain regions showed widespread repetition suppression for nonoverlapping pairs containing unique elements; however, the degree of repetition suppression was altered for overlapping pairs. Entorhinal cortex, perirhinal cortex (PRc), midbrain, and PRc-midbrain connectivity showed repetition-related increases across overlapping pairs. Notably, increased PRc activation for overlapping pairs tracked individual differences in the ability to reason about the relationships among pairs-our behavioral measure of memory integration. Within the hippocampus, activation increases across overlapping pairs were unique to CA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.