ArticleHippocampus2016
The effects of hippocampal lesions on MRI measures of structural and functional connectivity.
Article in Hippocampus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.Experimental neurology · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- What episodic memory reveals about the default mode network.Current opinion in behavioral sciences · 2026Article
- Statin Therapy Protects White Matter in Cerebral Small Vessel Disease Independent of Lipid-Lowering: Biomarker and Neuroimaging Evidence.Brain and behavior · 2026Article
- Collateral Damage: Neurological Correlates of Non-Fatal Overdose in the Era of Fentanyl-Xylazine.Neuroscience insights · 2024Article
- An In-depth Exploration of the Interplay between fMRI Methods and Theory in Cognitive Neuroscience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2024Article
- Immediate neural impact and incomplete compensation after semantic hub disconnection.Nature communications · 2023Article
- Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multi-band network fusion for Alzheimer's disease identification with functional MRI.Frontiers in psychiatry · 2022Article
- Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Functions of ventral visual cortex after bilateral medial temporal lobe damage.Progress in neurobiology · 2020Article
- Regions and Connections: Complementary Approaches to Characterize Brain Organization and Function.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020Review
- Article
- The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia.BioMed research international · 2020Article
- Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory.eLife · 2019Article
- Article
- Frequency-specific noninvasive modulation of memory retrieval and its relationship with hippocampal network connectivity.Hippocampus · 2019Article
- An enriched granger causal model allowing variable static anatomical constraints.NeuroImage. Clinical · 2019Article
- Subspecialization within default mode nodes characterized in 10,000 UK Biobank participants.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain.eLife · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Focal lesions can affect connectivity between distal brain regions (connectional diaschisis) and impact the graph-theoretic properties of major brain networks (connectomic diaschisis). Given its unique anatomy and diverse range of functions, the hippocampus has been claimed to be a critical "hub" in brain networks. We investigated the effects of hippocampal lesions on structural and functional connectivity in six patients with amnesia, using a range of magnetic resonance imaging (MRI) analyses. Neuropsychological assessment revealed marked episodic memory impairment and generally intact performance across other cognitive domains. The hippocampus was the only brain structure exhibiting reduced grey-matter volume that was consistent across patients, and the fornix was the only major white-matter tract to show altered structural connectivity according to both diffusion metrics. Nonetheless, functional MRI revealed both increases and decreases in functional connectivity. Analysis at the level of regions within the default-mode network revealed reduced functional connectivity, including between nonhippocampal regions (connectional diaschisis). Analysis at the level of functional networks revealed reduced connectivity between thalamic and precuneus networks, but increased connectivity between the default-mode network and frontal executive network. The overall functional connectome showed evidence of increased functional segregation in patients (connectomic diaschisis). Together, these results point to dynamic reorganization following hippocampal lesions, with both decreased and increased functional connectivity involving limbic-diencephalic structures and larger-scale networks. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.