ArticleMolecular microbiology2016
Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans.
Article in Molecular microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
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- D-lactic acid inhibits Candida albicans associated with vulvovaginal candidiasis: in vitro and in vivo effects and underlying mechanisms.BMC microbiology · 2025Article
- Anti-Microorganisms · 2023Article
- Bacterial-fungal interactions and their impact on microbial pathogenesis.Molecular ecology · 2023Review
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- Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2023Article
- Intestinal bacteria-a powerful weapon for fungal infections treatment.Frontiers in cellular and infection microbiology · 2023Review
- The Role ofPathogens (Basel, Switzerland) · 2022Article
- Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture SystemMicrobiology spectrum · 2022Article
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- Habitat Elevation Shapes Microbial Community Composition and Alter the Metabolic Functions in Wild Sable (Animals : an open access journal from MDPI · 2021Article
- It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled WithFrontiers in microbiology · 2021Review
- Interactions between invasive fungi and symbiotic bacteria.World journal of microbiology & biotechnology · 2020Review
- FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal.Frontiers in microbiology · 2020Article
- Genetic regulation of the development of mating projections inEmerging microbes & infections · 2020Article
- The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2019Review
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Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Microorganisms rarely exist as single species in natural environments. The opportunistic fungal pathogen Candida albicans and lactic acid bacteria (LAB) are common members of the microbiota of several human niches such as the mouth, gut and vagina. Lactic acid bacteria are known to suppress filamentation, a key virulence feature of C. albicans, through the production of lactic acid and other metabolites. Here we report that C. albicans cells switch between two heritable cell types, white and opaque, to undergo filamentation to adapt to diversified environments. We show that acidic pH conditions caused by LAB and low temperatures support opaque cell filamentation, while neutral pH conditions and high temperatures promote white cell filamentation. The cAMP signalling pathway and the Rfg1 transcription factor play major roles in regulating the responses to these conditions. This cell type-specific response of C. albicans to different environmental conditions reflects its elaborate regulatory control of phenotypic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.