ArticleCPT: pharmacometrics & systems pharmacology2016
Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration.
Article in CPT: pharmacometrics & systems pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Circadian considerations in antimicrobials.European journal of clinical pharmacology · 2026Review
- QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations.Journal of pharmacokinetics and pharmacodynamics · 2025Review
- Effective Visualizations Using "vachette" to Assess and Communicate Pharmacometric Model Results.The AAPS journal · 2025Article
- Circadian rhythms in cardiovascular disease.European heart journal · 2025Review
- Heart Failure, Kidney Function, and Elderly Age, Rather than Levofloxacin Therapy, Are Associated with QTc Prolongation in COVID-19 Patients.Journal of clinical medicine · 2025Article
- The effect of pregnancy on the population pharmacokinetics of levofloxacin in South Africans with rifampicin-resistant tuberculosis.Antimicrobial agents and chemotherapy · 2025Article
- A case with a trend of QT interval prolongation due to the introduction of methadone to a pancreatic cancer patient on levofloxacin.Journal of pharmaceutical health care and sciences · 2024Article
- The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care.Journal of biological rhythms · 2022Review
- How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- The power of modelling pulsatile profiles.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Prediction of potential drug interactions between repurposed COVID-19 and antitubercular drugs: an integrational approach of drug information software and computational techniques data.Therapeutic advances in drug safety · 2021Article
- Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria.Antimicrobial agents and chemotherapy · 2020Article
- Measurement and Management of QT Interval Prolongation for General Physicians.Journal of general internal medicine · 2020Review
- Evaluation of QT Liability for PF-05251749 in the Presence of Potential Circadian Rhythm Modification.CPT: pharmacometrics & systems pharmacology · 2020Article
- Response to "Time of the Day and Magnitude of the Effect of a Drug on the QTc Interval".CPT: pharmacometrics & systems pharmacology · 2017Article
- Time of the Day and Magnitude of the Effect of a Drug on the QTc Interval.CPT: pharmacometrics & systems pharmacology · 2017Article
- Commentary on: "Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration".CPT: pharmacometrics & systems pharmacology · 2016Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a randomized, crossover, clinical trial was conducted in which 12 healthy male subjects received levofloxacin at 02:00, 06:00, 10:00, 14:00, 18:00, and 22:00. Using a pharmacokinetic-pharmacodynamic (PK-PD) modeling approach to account for variations in PKs, heart rate, and daily variation in baseline QT, we find that the concentration-QT relationship shows a 24-hour sinusoidal rhythm. Simulations show that the extent of levofloxacin-induced QT prolongation depends on dosing time, with the largest effect at 14:00 (1.73 (95% prediction interval: 1.56-1.90) ms per mg/L) and the smallest effect at 06:00 (-0.04 (-0.19 to 0.12) ms per mg/L). These results suggest that a 24-hour variation in the concentration-QT relationship could be a potentially confounding factor in the assessment of drug-induced QTc prolongation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.