ArticleNature biotechnology2016
Engineered non-Mendelian inheritance of entire parental genomes in C. elegans.
Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.Current biology : CB · 2026Article
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- A default silencing mechanism restrains stress-induced genes inbioRxiv : the preprint server for biology · 2025Article
- Nucleus-independent transgenerational small RNA inheritance inScience advances · 2023Article
- Characterizing short germline-specific promoters with a range of expression levels inmicroPublication biology · 2023Article
- Article
- An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.Developmental cell · 2021Article
- Mating can initiate stable RNA silencing that overcomes epigenetic recovery.Nature communications · 2021Article
- Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Assessment and Maintenance of Unigametic Germline Inheritance for C. elegans.Developmental cell · 2019Article
- Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans.Developmental cell · 2019Article
- Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells.Biomolecules · 2019Review
- G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity.Journal of developmental biology · 2018Review
- Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis.Nature communications · 2018Article
- Genetic engineering: Rewriting the rules of inheritance.Nature reviews. Genetics · 2016Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to rewrite the rules of genetic segregation would open new possibilities in diverse areas of biotechnology ranging from breeding to epigenetics. Here we engineer non-Mendelian inheritance of the entire maternal or paternal genome in Caenorhabditis elegans by changing the structure of the mitotic spindle during the first cell division of the zygote. Using germline-specific overexpression of a single protein, the conserved microtubule force regulator GPR-1, we increase forces that pull on spindle poles to convert the single bipolar mitotic spindle to two monopolar spindles. This generates two-cell embryos in which one cell contains only the maternal chromosomes and the other cell contains only the paternal chromosomes. As the embryo develops, each cell of the animal, including the germ cells, contains the genetic material of only one parent, resulting in hybrid F1 animals. Progeny of these animals (F2) inherit either only F0 maternal or only F0 paternal chromosomes, and thus descend from only either of their grandparents' gametes.
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