ArticleLaboratory investigation; a journal of technical methods and pathology2016
Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties.
Article in Laboratory investigation; a journal of technical methods and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models.Restorative dentistry & endodontics · 2026Article
- Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges.Tissue engineering and regenerative medicine · 2025Review
- Durable disease regression with copanlisib treatment in PI3K-mutated metastasizing ameloblastoma: A case report.Rare tumors · 2025Article
- From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration.Stem cell reviews and reports · 2024Review
- Immortalized cell lines derived from dental/odontogenic tissue.Cell and tissue research · 2023Review
- Advances in tooth agenesis and tooth regeneration.Regenerative therapy · 2023Review
- A Combinatorial Approach to Regenerate the Periodontal Ligament and Cementum in a Nondental Microenvironment.Journal of tissue engineering and regenerative medicine · 2023Article
- Novel approaches for periodontal tissue engineering.Genesis (New York, N.Y. : 2000) · 2022Review
- Organoids from human tooth showing epithelial stemness phenotype and differentiation potential.Cellular and molecular life sciences : CMLS · 2022Article
- Analysis of the cells isolated from epithelial cell rests of Malassez through single-cell limiting dilution.Scientific reports · 2022Article
- Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome.Frontiers in physiology · 2022Article
- Establishment of inclusive single-cell transcriptome atlases from mouse and human tooth as powerful resource for dental research.Frontiers in cell and developmental biology · 2022Article
- From Bite to Byte: Dental Structures Resolved at a Single-Cell Resolution.Journal of dental research · 2021Review
- A single-cell atlas of human teeth.iScience · 2021Article
- Direct reprogramming of epithelial cell rests of malassez into mesenchymal-like cells by epigenetic agents.Scientific reports · 2021Article
- Epithelial Cell Rests of Malassez Provide a Favorable Microenvironment for Ameliorating the Impaired Osteogenic Potential of Human Periodontal Ligament Stem Cells.Frontiers in physiology · 2021Article
- Exosome-like vesicles derived from Hertwig's epithelial root sheath cells promote the regeneration of dentin-pulp tissue.Theranostics · 2020Article
- Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update.Stem cells international · 2020Review
- Isolation and characterization of cells derived from human epithelial rests of Malassez.Odontology · 2019Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial cell rests of Malassez (ERM) are quiescent epithelial remnants of the Hertwig's epithelial root sheath (HERS) that are involved in the formation of tooth roots. ERM cells are unique epithelial cells that remain in periodontal tissues throughout adult life. They have a functional role in the repair/regeneration of cement or enamel. Here, we isolated odontogenic epithelial cells from ERM in the periodontal ligament, and the cells were spontaneously immortalized. Immortalized odontogenic epithelial (iOdE) cells had the ability to form spheroids and expressed stem cell-related genes. Interestingly, iOdE cells underwent osteogenic differentiation, as demonstrated by the mineralization activity in vitro in mineralization-inducing media and formation of calcification foci in iOdE cells transplanted into immunocompromised mice. These findings suggest that a cell population with features similar to stem cells exists in ERM and that this cell population has a differentiation capacity for producing calcifications in a particular microenvironment. In summary, iOdE cells will provide a convenient cell source for tissue engineering and experimental models to investigate tooth growth, differentiation, and tumorigenesis.
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