Evidence map›Paper›PMID 27478997›Full record

ArticleAIDS research and human retroviruses2017

Acute Kidney Injury, Risk Factors, and Prognosis in Hospitalized HIV-Infected Adults in South Africa, Compared by Tenofovir Exposure.

Faheem Seedat, Neil Martinson, Katlego Motlhaoleng, Pattamukkil Abraham, Dalu Mancama, Saraladevi Naicker, Ebrahim Variava

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020
    Article
  7. HIV, drugs and the kidney.Drugs in context · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Faheem Seedat1 Department of Internal Medicine, Faculty of Health Sciences, University of Witwatersrand , Johannesburg, South Africa .
Neil Martinson2 Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand , Johannesburg, South Africa .
Katlego Motlhaoleng2 Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand , Johannesburg, South Africa .
Pattamukkil Abraham2 Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand , Johannesburg, South Africa .
Dalu Mancama4 Council for Scientific and Industrial Research , Pretoria, South Africa .
Saraladevi Naicker1 Department of Internal Medicine, Faculty of Health Sciences, University of Witwatersrand , Johannesburg, South Africa .
Ebrahim Variava1 Department of Internal Medicine, Faculty of Health Sciences, University of Witwatersrand , Johannesburg, South Africa .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are limited data describing acute kidney injury (AKI) in HIV-infected adult patients in resource-limited settings where tenofovir disoproxil fumarate (TDF), which is potentially nephrotoxic, is increasingly prescribed. We describe risk factors for and prognosis of AKI in HIV-infected individuals, stratified by those receiving and those naive to TDF. A prospective case cohort study of hospitalized HIV-infected adults with AKI stratified by TDF exposure. Adults (≥18 years) were recruited: clinical and biochemical data were collected at admission; their renal recovery, discharge, or mortality was ascertained as an in-patient and, subsequently, to a scheduled 3-month follow-up. Among this predominantly female (61%), almost exclusively black African cohort of 175 patients with AKI, 93 (53%) were TDF exposed; median age was 41 years (interquartile range 35-50). Median CD4 count and viral load and creatinine at baseline were 116 cells/mm

Indexed as

HospitalizationAcute Kidney InjuryAdolescentAdultAnti-HIV AgentsFemaleHIV InfectionsHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsSurvival AnalysisTenofovirTuberculosisAnti-HIV AgentsTenofoviracute kidney injuryHIVmortalityrenal insufficiencySouth Africatenofovir

Identifiers

PMID27478997
PMCPMC5240010

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.