Evidence map›Paper›PMID 27478970›Full record

ArticleEpigenomics2016

Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals.

Yuanyuan Li, Phillip Buckhaults, Xiangqin Cui, Trygve O Tollefsbol

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  17. Green Tea Polyphenols Promote Functional Recovery from Peripheral Nerve Injury in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yuanyuan LiDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Phillip BuckhaultsDepartment of Drug Discovery & Biomedical Sciences, University of South Carolina, Columbia, SC 29208, USA.
Xiangqin CuiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Trygve O TollefsbolDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USUniversity of South Carolina · US

Funding

Combinatorial epigenetic-based prevention of breast cancerR01CA178441 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TOLLEFSBOL, TRYGVE O · 2014 to 2025
$3.2M
A Genetic Model for Early-Onset Breast and Colon Cancer in African AmericansU01CA158428 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BUCKHAULTS, PHILLIP JOE, BUNZ, FRED · 2012 to 2016
$1.5M
Maternal epigenetic dietary effects on early breast cancer preventionR03CA176766 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YUANYUAN · 2013 to 2014
$145k
NCI NIH HHS R01 CA178441NCI NIH HHS R03 CA176766NCI NIH HHS U01 CA158428
6 · The paper itself

Abstract

aimAberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioactive dietary components including green tea polyphenols (GTPs) and broccoli sprouts (BSp) on neutralizing epigenetic aberrations during breast tumorigenesis. MATERIALS &

methodsThe combinatorial effects were evaluated in a breast cancer transformation cellular system and breast cancer mouse xenografts. RESULTS &

conclusionCombined treatment with epigallocatechin-3-gallate in GTPs and sulforaphane in BSp resulted in a synergistic inhibition of breast cancer cellular growth. Further studies revealed this combination led to genome-wide epigenetic alterations. Combinatorial diets significantly inhibited tumor growth in breast cancer mouse xenografts. Collectively, these studies indicate that combined GTPs and BSp are highly effective in inhibiting early breast cancer development by, at least in part, regulating epigenetic mechanisms.

Indexed as

Epigenesis, GeneticAnimalsAntineoplastic Agents, PhytogenicBrassicaBreast NeoplasmsCarcinogenesisCatechinCell ProliferationCells, CulturedDrug Therapy, CombinationFemaleHumansIsothiocyanatesMiceMice, NudeSulfoxidesAntineoplastic Agents, PhytogenicCatechinepigallocatechin gallateIsothiocyanatessulforaphaneSulfoxidesTeabreast tumorigenesisbroccoli sproutsEGCGepigeneticgreen tea polyphenolssulforaphane

Identifiers

PMID27478970
PMCPMC5066124
OpenAlexW2502571399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.