Evidence map›Paper›PMID 27478867›Full record

ArticleACS infectious diseases2016

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen.

Noton K Dutta, Rongjun He, Michael L Pinn, Yantao He, Francis Burrows, Zhong-Yin Zhang, Petros C Karakousis

Abstract read
In one paragraph

Article in ACS infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Secreted proteins ofFrontiers in tuberculosis · 2026
    Review
  3. Article
  4. Article
  5. Combating Tuberculosis via Restoring the Host Immune Capacity by TargetingInternational journal of molecular sciences · 2024
    Review
  6. Article
  7. Shikonin and Juglone InhibitBiotech (Basel (Switzerland)) · 2023
    Article
  8. Article
  9. Different modalities of host cell death and their impact onAmerican journal of physiology. Cell physiology · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. One Size Fits All? Not inFrontiers in cellular and infection microbiology · 2021
    Review
  14. Review
  15. Highly Potent and SelectiveJournal of medicinal chemistry · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Targeting Tyrosine Phosphatases: Time to End the Stigma.Trends in pharmacological sciences · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Noton K DuttaCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rongjun HeDepartment of Biochemistry and Molecular Biology Indiana University School of Medicine, Indianapolis, IN, USA.
Michael L PinnCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yantao HeDepartment of Biochemistry and Molecular Biology Indiana University School of Medicine, Indianapolis, IN, USA.
Francis BurrowsAarden Pharmaceuticals, Inc. Indianapolis, IN, USA.
Zhong-Yin ZhangDepartment of Biochemistry and Molecular Biology Indiana University School of Medicine, Indianapolis, IN, USA.
Petros C KarakousisCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Indiana University School of MedicineJohns Hopkins Medicine · USIndiana University – Purdue University Indianapolis · USJohns Hopkins University · US

Funding

Structure/Function of Protein Tyrosine PhosphatasesR01CA069202 · NCI · YESHIVA UNIVERSITY · PI Zhong-Yin Zhang · 1996 to 2026
$7.3M
Statins as Adjunctive, Host-Directed Therapy for TBUH2AI122309 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2015 to 2016
$1.2M
NCI NIH HHS R01 CA069202NIAID NIH HHS UH2 AI122309
6 · The paper itself

Abstract

Novel drugs are required to shorten the duration of treatment for tuberculosis (TB) and to combat the emergence of drug resistance. One approach has been to identify and target

Indexed as

activitybactericidalchemotherapyguinea piginhibitorsisoniazidMycobacterium tuberculosispharmacokineticsprotein tyrosine phosphatasespyrazinamiderifampinsterilizingvirulence factors

Identifiers

PMID27478867
PMCPMC4966677
OpenAlexW2223940912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.