Trial reportBioMed research international2016
Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study.
Trial report in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Regenerative Therapies for Basal Thumb Arthritis-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Platelet-Rich Plasma in Plastic Surgery: A Systematic Review.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Pooled it
- Trial
- Safety and efficacy of platelet-rich plasma injections in basal thumb osteoarthritis; should we offer it or not?Journal of hand and microsurgery · 2025Review
- Comparison between intra-articular injections of corticosteroids, hyaluronic acid, PRP and placebo for thumb base osteoarthritis: A frequentist network meta-analysis.Journal of orthopaedics · 2023Review
- Review
- Platelet-Rich Plasma Injection for Thumb Carpometacarpal Joint Osteoarthritis.Archives of rehabilitation research and clinical translation · 2023Article
- Liparthroplasty for Thumb Carpometacarpal Joint Osteoarthritis: A Case Series with Median 5 Years of Follow-Up.Journal of clinical medicine · 2022Article
- Article
- [Conservative treatment options for symptomatic thumb trapeziometacarpal joint osteoarthritis].Der Orthopade · 2022Review
- Platelet-Rich Plasma Does Not Inhibit Inflammation or Promote Regeneration in Human Osteoarthritic ChondrocytesCartilage · 2021Article
- New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?Frontiers in pharmacology · 2021Review
- Suspension arthroplasty in the treatment of thumb carpometacarpal osteoarthritis.Orthopedic reviews · 2020Article
- Platelet-rich plasma for thumb carpometacarpal joint osteoarthritis in a professional pianist: case-based review.Rheumatology international · 2019Review
- Osteoarthritis year in review 2017: clinical.Osteoarthritis and cartilage · 2018Review
- Current trends in the management of trapeziometacarpal arthritis.Orthopedic reviews · 2017Article
- Platelet-Rich Plasma as an Autologous and Proangiogenic Cell Delivery System.Mediators of inflammation · 2017Article
- Optimal management of thumb basal joint arthritis: challenges and solutions.Orthopedic research and reviews · 2017Review
- Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease.Mediators of inflammation · 2017Article
- Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma.Journal of orthopaedicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years. The purpose of this study was to evaluate PRP injection into the trapeziometacarpal (TMC) joint. We report about ten patients with TMC joint osteoarthritis (OA) that were treated with 2 intra-articular PRP injections 4 weeks apart. PRP was produced using the Double Syringe System (Arthrex Inc., Naples, Florida, USA). A total volume of 1.47 ± 0.25 mL PRP was injected at the first injection and 1.5 ± 0.41 mL at the second injection, depending on the volume capacity of the joint. Patients were evaluated using VAS, strength measures, and the Mayo Wrist score and DASH score after 3 and 6 months. VAS significantly decreased from 6.2 ± 1.6 to 5.4 ± 2.2 at six-month follow-up (P < 0.05). The DASH score was unaffected; however, the Mayo Wrist score significantly improved from 46.5 ± 18.6 to 67.5 ± 19.0 at six-month follow-up (P = 0.05). Grip was unaffected, whereas pinch declined from 6.02 ± 2.99 to 3.96 ± 1.77 at six-month follow-up (P < 0.05). We did not observe adverse events after the injection of PRP, except one occurrence of a palmar wrist ganglion, which resolved without treatment. PRP injection for symptomatic TMC OA is a reasonable therapeutic option in early stages TMC OA and can be performed with little to no morbidity.
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