ArticleBioMed research international2016
Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- The impact of subclinical hypothyroidism on core reproductive hormones and ovarian endocrine status in patients with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- The crosstalk between polycystic ovary syndrome and Hashimoto thyroiditis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Prevalence and Levels of Thyroid Autoantibodies in Polycystic Ovary Syndrome-Impact of TSH- and BMI-Matched Comparisons: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Prevalence of subclinical hypothyroidism in polycystic ovary syndrome and its impact on insulin resistance: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Correlation between Hashimoto's thyroiditis and polycystic ovary syndrome: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Body Mass Index-Related Alterations in Gonadotropin Secretion Among Women with Polycystic Ovary Syndrome Compared with Healthy Controls.Diseases (Basel, Switzerland) · 2026Article
- Thyroid Autoimmunity in Polycystic Ovary Syndrome: Phenotype Distribution, HDL-Cholesterol, and Data-Driven Clusters in a Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Subclinical Hypothyroidism in Polycystic Ovary Syndrome: Prevalence and Impact on Metabolic and Cardiovascular risk.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Correlation between thyroid hormone sensitivity and the risk of polycystic ovary syndrome.BMC endocrine disorders · 2024Article
- Endometriosis, polycystic ovary syndrome, and the thyroid: a review.Endocrine connections · 2024Review
- Maternal preconception thyroid autoimmunity is associated with neonatal birth weight conceived by PCOS women undergoing their first in vitro fertilization/intracytoplasmic sperm injection.Journal of ovarian research · 2023Article
- Polycystic Ovary Syndrome, Subclinical Hypothyroidism, the Cut-Off Value of Thyroid Stimulating Hormone; Is There a Link? Findings of a Population-Based Study.Diagnostics (Basel, Switzerland) · 2023Article
- The role of the thyroid in polycystic ovary syndrome.Frontiers in endocrinology · 2023Review
- Influence of Subclinical Hypothyroidism on Women With Polycystic Ovary Syndrome: A Literature Review.Cureus · 2022Review
- Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies.International journal of endocrinology · 2021Review
- The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome.International journal of endocrinology · 2021Article
- Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto's Thyroiditis: How Far Is Our Understanding?Frontiers in immunology · 2021Review
- Article
- Impact of Subclinical Hypothyroidism on Reproductive and Metabolic Parameters in Polycystic Ovary Syndrome - A Cross-sectional Study from Bangladesh.European endocrinology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of Study. To assess status of thyroid function and thyroid disorders particularly subclinical hypothyroidism (SCH) in subjects with polycystic ovarian syndrome (PCOS) and impact of SCH on various clinical and biochemical parameters and cardiovascular risk in PCOS. Methods. Hundred females diagnosed with PCOS as per Rotterdam criteria and 100 normal controls were recruited and were subjected to elaborate anthropometric, clinical, and biochemical assessment. Results. Notable findings included significantly higher frequency of subjects with subclinical hypothyroidism (p = 0.0002), autoimmune thyroiditis (p < 0.001), and goitre (p = 0.02) in polycystic ovarian syndrome subjects compared to control subjects. Further SCH PCOS subjects were found to harbor significantly higher HOMA-IR (p < 0.05) and frequency of subjects with dyslipidemia (p < 0.05) compared to both euthyroid PCOS and euthyroid control subjects. Though frequency of subjects with cardiovascular risk factors was higher in SCH PCOS group than euthyroid PCOS group, it failed to reach statistical significance. Conclusion. We concluded that PCOS is associated with high incidence of SCH and AIT compared to normal population and SCH poses increased risk of cardiovascular disorder in PCOS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.