Evidence map›Paper›PMID 27478681›Full record

ArticleJournal of clinical & cellular immunology2016

Impact of Depression and Inflammation on the Progression of HIV Disease.

Yainyrette Rivera-Rivera, Fabián J Vázquez-Santiago, Elinette Albino, María Del C Sánchez, Vanessa Rivera-Amill

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical & cellular immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05659472 (The Effect of Combination Mindfulness Spiritual-Based Cognitive Therapy Plus Hypnosis on Levels of Cortisol, Serotonin, and Depression Degree in HIV Patients With Depression), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05659472 nacompletednot on this mapstarted 2020, after this paper: background citation

The Effect of Combination Mindfulness Spiritual-Based Cognitive Therapy Plus Hypnosis on Levels of Cortisol, Serotonin, and Depression Degree in HIV Patients With Depression

TypeinterventionalSponsorHealth Technology Institute of Cendekia Utama KudusRan2020 to 2021Enrolled62ConditionsDepressionArmsCombination mindfulness spiritual-based cognitive therapy plus hypnosis, Mindfulness-based cognitive therapy
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  4. Exploratory Cohort Study of Depressive Symptoms in South Africans with HIV-1 Subtype C: Associations with Kynurenine Pathway Metabolites and Inflammatory Markers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yainyrette Rivera-RiveraDepartment of Basic Sciences, Ponce Health Sciences University/Ponce Research Institute, Ponce, PR 00716, USA.
Fabián J Vázquez-SantiagoDepartment of Basic Sciences, Ponce Health Sciences University/Ponce Research Institute, Ponce, PR 00716, USA.
Elinette AlbinoDepartment of Basic Sciences, Ponce Health Sciences University/Ponce Research Institute, Ponce, PR 00716, USA.
María Del C SánchezDepartment of Basic Sciences, Ponce Health Sciences University/Ponce Research Institute, Ponce, PR 00716, USA.
Vanessa Rivera-AmillDepartment of Basic Sciences, Ponce Health Sciences University/Ponce Research Institute, Ponce, PR 00716, USA.
Ponce Health Sciences University · PR

Funding

VIRUS E34 TAILSPIKE: MODULE FOR PROTEIN:LPS INTERACTIONP20RR016470 · NCRR · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI MEJIAS, IDA A · 2001 to 2011
$31.2M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., NOBOA, CARIAMARIE · 2012 to 2018
$23.2M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI TORRES-RUIZ, JOSE A · 2012 to 2018
$15.9M
RISE Option III: Ponce School of Medicine MBRS-RISE ProgramR25GM082406 · NIGMS · PONCE SCHOOL OF MEDICINE · PI APPLEYARD, CAROLINE B · 2008 to 2021
$9.5M
NCRR NIH HHS P20 RR016470NIGMS NIH HHS R25 GM082406NIMHD NIH HHS G12 MD007579NIMHD NIH HHS U54 MD007587
6 · The paper itself

Abstract

The human immunodeficiency virus type 1 (HIV-1) epidemic has negatively affected over 40 million people worldwide. Antiretroviral therapy (ART) has improved life expectancy and changed the outcome of HIV-1 infection, making it a chronic and manageable disease. However, AIDS and non-AIDS comorbid illnesses persist during the course of infection despite the use of ART. In addition, the development of neuropsychiatric comorbidities (including depression) by HIV-infected subjects significantly affects quality of life, medication adherence, and disease prognosis. The factors associated with depression during HIV-1 infection include altered immune response, the release of pro-inflammatory cytokines, and monoamine imbalance. Elevated plasma pro-inflammatory cytokine levels contribute to the development of depression and depressive-like behaviors in HIV

Indexed as

ARTChronic inflammationCytokinesDepressionHIV

Identifiers

PMID27478681
PMCPMC4966661
OpenAlexW2513113599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.