ArticleMolecular biology international2016
Total Protein Profile and Drug Resistance in Candida albicans Isolated from Clinical Samples.
Article in Molecular biology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecular Identification, Virulence Factors, and Antifungal Susceptibility Profiles ofAntibiotics (Basel, Switzerland) · 2026Article
- Antifungal Synergy: Mechanistic Insights into the R-1-R Peptide andInternational journal of molecular sciences · 2024Article
- Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis.mBio · 2024Article
- Beyond the usual suspects: emerging uropathogens in the microbiome age.Frontiers in urology · 2023Review
- Essential Oil and Supercritical Carbon Dioxide Extract of Grapefruit Peels Formulated forACS omega · 2022Article
- Complex Electromagnetic Fields ReduceBiomedicines · 2021Article
- The Antimicrobial and Wound Healing Potential ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Article
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Authors and funding
4 authors.
Funding
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Abstract
This study was done to assess the antifungal susceptibility of clinical isolates of Candida albicans and to evaluate its total protein profile based on morphological difference on drug resistance. Hundred and twenty clinical isolates of C. albicans from various clinical specimens were tested for susceptibility against four antifungal agents, namely, fluconazole, itraconazole, amphotericin B, and ketoconazole. A significant increase of drug resistance in clinical isolates of C. albicans was observed. The study showed 50% fluconazole and itraconazole resistance at 32 μg mL(-1) with a MIC50 and MIC90 values at 34 and 47 and 36 and 49 μg mL(-1), respectively. All isolates were sensitive to amphotericin B and ketoconazole. The SDS-PAGE protein profile showed a prevalent band of ~52.5 kDa, indicating overexpression of gene in 72% strains with fluconazole resistance. Since the opportunistic infections of Candida spp. are increasing along with drug resistance, the total protein profile will help in understanding the evolutionary changes in drug resistance and also to characterize them.
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Registered trials
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