ArticleClinical kidney journal2016
Formulas for fixing serum sodium: curb your enthusiasm.
Article in Clinical kidney journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- [Consensus recommendations on the diagnosis and treatment of hyponatremia from the Austrian Society for Nephrology 2024].Wiener klinische Wochenschrift · 2024Article
- Hypertonic Saline for Hyponatremia: Meeting Goals and Avoiding Harm.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Fatal case of hospital-acquired hypernatraemia in a neonate: lessons learned from a tragic error.Clinical kidney journal · 2021Article
- Edelman Revisited: Concepts, Achievements, and Challenges.Frontiers in medicine · 2021Review
- Article
- Bioelectrical Impedance Analysis Is Not Sufficient for Determining Water Deficit in Hypernatremic Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Treatment of severe symptomatic hyponatremia.Physiological reports · 2019Article
- A quantitative approach to intravenous fluid therapy in the syndrome of inappropriate antidiuretic hormone secretion.Clinical and experimental nephrology · 2019Article
- Fluid balance concepts in medicine: Principles and practice.World journal of nephrology · 2018Review
- Testing NaClinical kidney journal · 2017Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of formulas have been proposed to predict changes in serum sodium concentration. All are based on an experiment done over 50 years ago by Edelman, who derived a formula relating the plasma sodium concentration to isotopically measured body sodium, potassium, and water. Some of these formulas fail because they do not include urinary losses of electrolytes and water. Even those that include these essential variables are not accurate enough for clinical use because it is impractical to adjust calculations to rapid changes in urinary composition, and because the formulas do not account for changes in serum sodium caused by internal exchanges between soluble and bound sodium stores or shifts of water into or out of cells resulting from changes in intracellular organic osmolytes. Nephrologists should curb their enthusiasm for predictive formulas and rely instead on frequent measurements of the serum sodium when correcting hyponatremia and hypernatremia.
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Registered trials
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