ArticleEuropean journal of translational myology2016
Physical Activity Counteracts Tumor Cell Growth in Colon Carcinoma C26-Injected Muscles: An Interim Report.
Article in European journal of translational myology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Voluntary exercise does not improve muscular properties or functional capacity during C26-induced cancer cachexia in mice.Journal of muscle research and cell motility · 2021Article
- A Pound of Flesh: What Cachexia Is and What It Is Not.Diagnostics (Basel, Switzerland) · 2021Review
- Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation.International journal of molecular sciences · 2020Article
- Therapeutic strategies against cancer cachexia.European journal of translational myology · 2019Article
- 2019Spring PaduaMuscleDays: Translational Myology and Mobility Medicine.European journal of translational myology · 2019Article
- Muscle spindles of the rat sternomastoid muscle.European journal of translational myology · 2018Article
- Report on Abstracts of the 15th Meeting of IIM, the Interuniversity Institute of Myology - Assisi (Italy), October 11-14, 2018.European journal of translational myology · 2018Article
- Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths?European journal of translational myology · 2018Article
- Chemotherapy-induced muscle wasting: an update.European journal of translational myology · 2018Article
- From Ejtm (European Journal of Translational Myology) to Ejt3M (European Journal of Translational Myology, Mobility, Medicine).European journal of translational myology · 2018Article
- Revisiting the peculiar regional distribution of muscle fiber types in rat Sternomastoid Muscle.European journal of translational myology · 2018Article
- Exciting perspectives for Translational Myology in the Abstracts of the 2018Spring PaduaMuscleDays: Giovanni Salviati Memorial - Chapter I - Foreword.European journal of translational myology · 2018Article
- Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle.Oxidative medicine and cellular longevity · 2018Article
- Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments.European journal of translational myology · 2017Article
- Of Faeces and Sweat. How Much a Mouse is Willing to Run: Having a Hard Time Measuring Spontaneous Physical Activity in Different Mouse Sub-Strains.European journal of translational myology · 2017Article
- FES in Europe and Beyond: Current Translational Research.European journal of translational myology · 2016Article
- Use it or Lose It: Tonic Activity of Slow Motoneurons Promotes Their Survival and Preferentially Increases Slow Fiber-Type Groupings in Muscles of Old Lifelong Recreational Sportsmen.European journal of translational myology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome. Beneficial effects of physical activity in counteracting cancer-related muscle wasting have been described in the last decades. Recently it has been shown that, in tumor xeno-transplanted mouse models, physical activity is able to directly affect tumor growth by modulating inflammatory responses in the tumor mass microenvironment. Here, we investigated the effect of physical activity on tumor cell growth in colon carcinoma C26 cells injected tibialis anterior muscles of BALB/c mice. Histological analyses revealed that 4 days of voluntary wheel running significantly counteracts tumor cell growth in C26-injected muscles compared to the non-injected sedentary controls. Since striated skeletal muscle tissue is the site of voluntary contraction, our results confirm that physical activity can also directly counteract tumor cell growth in a metabolically active tissue that is usually not a target for metastasis.
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