ArticleEvidence-based complementary and alternative medicine : eCAM2016
α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell.
Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Bioactive Plant-Derived Compounds as Novel Perspectives in Oral Cancer Alternative Therapy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- α-Mangostin: A Xanthone Derivative in Mangosteen with Potent Anti-Cancer Properties.Biomolecules · 2024Review
- Formulation of 1% α-mangostin in orabase gel induces apoptosis in oral squamous cell carcinoma.BMC complementary medicine and therapies · 2024Article
- Newly designed nanoparticle-drug delivery systems againstInternational journal of clinical and experimental pathology · 2024Review
- α-Mangostin Inhibits the Activation of Myofibroblasts via Downregulation of Linc-ROR-Mediated TGFB1/Smad Signaling.Nutrients · 2023Article
- Xanthones fromInternational journal of molecular sciences · 2023Article
- Natural Products as Anticancer Agents: Current Status and Future Perspectives.Molecules (Basel, Switzerland) · 2022Review
- Suppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway.BMC cancer · 2022Article
- Article
- Leaf extract of Osbeckia octandra induces apoptosis in oral squamous cell carcinoma cells.BMC complementary medicine and therapies · 2022Article
- The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones.Pharmacological research · 2022Review
- Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The PolyphenolsMolecules (Basel, Switzerland) · 2021Article
- Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment.BMC oral health · 2021Article
- Electroacupuncture Pretreatment Regulates Apoptosis of Myocardial Ischemia-Reperfusion Injury in Rats Through RhoA/p38MAPK Pathway Mediated by miR-133a-5p.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Cytotoxic Effects of Mangosteen Pericarp Extracts on Oral Cancer and Cervical Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- α-Mangostin reduced the viability of A594 cells in vitro by provoking ROS production through downregulation of NAMPT/NAD.Cell stress & chaperones · 2020Article
- Nanoparticle Drug Delivery Systems for α-Mangostin.Nanotechnology, science and applications · 2020Review
- A Novel Biological Role of α-Mangostin via TAK1-NF-κB Pathway against Inflammatory.Inflammation · 2019Article
- Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines.Evidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mangosteen has long been used as a traditional medicine and is known to have antibacterial, antioxidant, and anticancer effects. Although the effects of α-mangostin, a natural compound extracted from the pericarp of mangosteen, have been investigated in many studies, there is limited data on the effects of the compound in human oral squamous cell carcinoma (OSCC). In this study, α-mangostin was assessed as a potential anticancer agent against human OSCC cells. α-Mangostin inhibited cell proliferation and induced cell death in OSCC cells in a dose- and time-dependent manner with little to no effect on normal human PDLF cells. α-Mangostin treatment clearly showed apoptotic evidences such as nuclear fragmentation and accumulation of annexin V and PI-positive cells on OSCC cells. α-Mangostin treatment also caused the collapse of mitochondrial membrane potential and the translocation of cytochrome c from the mitochondria into the cytosol. The expressions of the mitochondria-related proteins were activated by α-mangostin. Treatment with α-mangostin also induced G1 phase arrest and downregulated cell cycle-related proteins (CDK/cyclin). Hence, α-mangostin specifically induces cell death and inhibits proliferation in OSCC cells via the intrinsic apoptosis pathway and cell cycle arrest at the G1 phase, suggesting that α-mangostin may be an effective agent for the treatment of OSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.