ArticleArchives of medical science : AMS2016
Cognitive variations among vascular dementia subtypes caused by small-, large-, or mixed-vessel disease.
Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Cognitive screening for cardiovascular risk stratification in stable coronary artery disease: a prospective cohort study.Archives of medical science : AMS · 2026Article
- Serum Homocysteine as a Potential Dynamic Biomarker for Staging and Monitoring Progression in Alzheimer's Disease.Neuropsychiatric disease and treatment · 2026Article
- Hyperhomocysteinemia and Disease-Is 10 μmol/L a Suitable New Threshold Limit?International journal of molecular sciences · 2024Review
- Frailty Is Associated With Cognitive Decline Independent of Cerebral Small Vessel Disease and Brain Atrophy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Cognitive Profile of Large-Vessel Vascular Dementia-An Observational Study from a Tertiary Care Center in Kolkata.Journal of neurosciences in rural practice · 2022Article
- Blood and CSF Homocysteine Levels in Alzheimer's Disease: A Meta-Analysis and Meta-Regression of Case-Control Studies.Neuropsychiatric disease and treatment · 2022Review
- Pharmaceutical and pharmacological studies of Shen Ma Yi Zhi granule for prevention of vascular dementia: A review.Frontiers in neuroscience · 2022Review
- Effect of interactions betweenArchives of medical science : AMS · 2021Article
- Heat therapy: possible benefits for cognitive function and the aging brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Lower retinal capillary density in minimal cognitive impairment among older Latinx adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Pattern of cognitive deficits in vascular dementia.The Indian journal of medical research · 2019Article
- Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit.Vascular health and risk management · 2019Review
- Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia.Archives of medical science : AMS · 2017Article
- Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review.Current hypertension reports · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVascular dementia (VaD) is a heterogeneous disease that can vary in clinical presentation and cognitive profile. The cognitive profiles of different VaD subtypes depend on the anatomical distribution of the vascular insults that have been documented. MATERIAL AND
methodsWe reviewed demographic, cognitive, and imaging data in 402 patients who were clinically diagnosed with VaD between January 2002 and June 2012 at the First Affiliated Hospital of Gan Nan Medical College in Ganzhou, China.
resultsBased on magnetic resonance imaging (MRI) results, patients were classified as having large- (24.1%), small- (70.4%), or mixed-vessel VaD (5.5%). Hypertension was the most prevalent risk factor (81%), followed by smoking (37%), hyperlipidemia (35%), and diabetes (27%). Hyperlipidemia, cardiac risk factors (history of cardiovascular disease, heart valve disorder) and carotid stenosis were more frequent in patients with large-vessel disease compared to those with small-vessel or mixed-vessel disease (p < 0.001). A median of 4 (maximum 11) cognitive domains were impaired in each VaD patient. After memory dysfunction, executive defects were the most prevalent (68.9%), and neurobehavioral dysfunction was the most rare (13.2%). Patients with small-vessel VaD showed more executive dysfunction than patients with large-vessel and mixed-vessel VaD (p < 0.05), whereas patients with large-vessel VaD had a higher prevalence of visuospatial or language dysfunction (p < 0.05).
conclusionsThe results indicate that specific subtypes and underlying vascular mechanisms will help predict clinical courses and produce more focused treatment and prevention of VaD.
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