ArticleArchives of medical science : AMS2016
Effect of comprehensive cardiovascular disease risk management on longitudinal changes in carotid artery intima-media thickness in a community-based prevention clinic.
Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
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- The underlying mechanisms of FGF2 in carotid atherosclerotic plaque development revealed by bioinformatics analysis.Archives of medical science : AMS · 2024Article
- The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress.Frontiers in cardiovascular medicine · 2022Review
- Microvascular disease confers additional risk to COVID-19 infection.Medical hypotheses · 2020Article
- Three-dimensional ultrasonographic evaluation of carotid artery plaque surface irregularity.Archives of medical science : AMS · 2020Article
- Cardiovascular Prevention: Migrating From a Binary to a Ternary Classification.Frontiers in cardiovascular medicine · 2020Article
- Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors.Archives of medical science : AMS · 2019Article
- Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis.Archives of medical science : AMS · 2019Article
- Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.Archives of medical science : AMS · 2018Article
- A population-based screening study for cardiovascular diseases and diabetes in Danish postmenopausal women: acceptability and prevalence.BMC cardiovascular disorders · 2018Observational
- Precision Healthcare of Type 2 Diabetic Patients Through Implementation of Haptoglobin Genotyping.Frontiers in cardiovascular medicine · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the study was to examine changes in carotid intima-media thickness (CIMT) and carotid plaque morphology in patients receiving multifactorial cardiovascular disease (CVD) risk factor management in a community-based prevention clinic. Quantitative changes in CIMT and qualitative changes in carotid plaque morphology may be measured non-invasively by ultrasound. MATERIAL AND
methodsThis is a retrospective study on a cohort of 324 patients who received multifactorial cardiovascular risk reduction treatment at a community prevention clinic. All patients received lipid-lowering medications (statin, niacin, and/or ezetimibe) and lifestyle modification. All patients underwent at least one follow-up CIMT measurement after starting their regimen. Annual biomarker, CIMT, and plaque measurements were analyzed for associations with CVD risk reduction treatment.
resultsMedian time to last CIMT was 3.0 years. Compared to baseline, follow-up analysis of all treatment groups at 2 years showed a 52.7% decrease in max CIMT, a 3.0% decrease in mean CIMT, and an 87.0% decrease in the difference between max and mean CIMT (p < 0.001). Plaque composition changes occurred, including a decrease in lipid-rich plaques of 78.4% within the first 2 years (p < 0.001). After the first 2 years, CIMT and lipid-rich plaques continued to decline at reduced rates.
conclusionIn a cohort of patients receiving comprehensive CVD risk reduction therapy, delipidation of subclinical carotid plaque and reductions in CIMT predominantly occurred within 2 years, and correlated with changes in traditional biomarkers. These observations, generated from existing clinical data, provide unique insight into the longitudinal on-treatment changes in carotid plaque.
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