Evidence map›Paper›PMID 27478429›Full record

ArticleAdvanced functional materials2016

Label-Free and Continuous-Flow Ferrohydrodynamic Separation of HeLa Cells and Blood Cells in Biocompatible Ferrofluids.

Wujun Zhao, Taotao Zhu, Rui Cheng, Yufei Liu, Jian He, Hong Qiu, Lianchun Wang, Tamas Nagy, Troy D Querec, Elizabeth R Unger and 1 more

Abstract read
In one paragraph

Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Wujun ZhaoDepartment of Chemistry, The University of Georgia Athens, GA 30602, USA.
Taotao ZhuDepartment of Chemistry, The University of Georgia Athens, GA 30602, USA.
Rui ChengCollege of Engineering, The University of Georgia, 220 Riverbend Road Room, 166, Athens, GA 30602, USA.
Yufei LiuDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
Jian HeDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
Hong QiuDepartment of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602, USA.
Lianchun WangDepartment of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602, USA.
Tamas NagyDepartment of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA.
Troy D QuerecChronic Viral Diseases Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic, Infectious Diseases Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Elizabeth R UngerChronic Viral Diseases Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic, Infectious Diseases Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Leidong MaoCollege of Engineering, The University of Georgia, 220 Riverbend Road Room, 166, Athens, GA 30602, USA.
University of Georgia · USClemson University · USCenters for Disease Control and Prevention · USNational Center for Emerging and Zoonotic Infectious Diseases · US

Funding

ZINC DEFICIENCY &PROTEIN EXPRESSION IN RAT OLFACTORY BULBSP41RR005351 · NCRR · UNIVERSITY OF GEORGIA (UGA) · PI VENOT, ANDRE · 1989 to 2011
$18.4M
TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
Robo4 and heparan sulfate proteoglycan in angiogenesisR01HL093339 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LIANCHUN · 2009 to 2018
$3.4M
INTEGRATED FERROFLUIDIC MICROCHIP FOR CELL MANIPULATION AND ENRICHMENTR21GM104528 · NIGMS · UNIVERSITY OF GEORGIA · PI CHEN, JI, JANSEN, BEN H. · 2012 to 2014
$625k
Using CRISPR-Cas9 technology to develop a mutant cell library for heparan sulfate structure-function studyR21HL131553 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, LIANCHUN · 2015 to 2016
$582k
Intramural CDC HHS CC999999NCRR NIH HHS P41 RR005351NHLBI NIH HHS R01 HL093339NHLBI NIH HHS R21 HL131553NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R21 GM104528
6 · The paper itself

Abstract

In this study, a label-free, low-cost, and fast ferrohydrodynamic cell separation scheme is demonstrated using HeLa cells (an epithelial cell line) and red blood cells. The separation is based on cell size difference, and conducted in a custom-made biocompatible ferrofluid that retains the viability of cells during and after the assay for downstream analysis. The scheme offers moderate-throughput (≈10

Identifiers

PMID27478429
PMCPMC4963013
OpenAlexW2191435227

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.