ArticleNeuron2016
Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Gene expression programs underlying spinal commissural neuron differentiation and axon growth across the midline.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A spinal substrate for modular control of natural behavior.bioRxiv : the preprint server for biology · 2026Article
- Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord.bioRxiv : the preprint server for biology · 2026Article
- Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026Article
- Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.Frontiers in neural circuits · 2026Article
- Review
- A harmonized atlas of mouse spinal cord cell types and their spatial organization.Nature communications · 2021Article
- Future Tail Tales: A Forward-Looking, Integrative Perspective on Tail Research.Integrative and comparative biology · 2021Review
- Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and CaInternational journal of molecular sciences · 2021Article
- Article
- Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.International journal of molecular sciences · 2021Review
- A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits.PLoS genetics · 2021Article
- Article
- Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.Nature reviews. Neuroscience · 2019Review
- Positional Strategies for Connection Specificity and Synaptic Organization in Spinal Sensory-Motor Circuits.Neuron · 2019Article
- Cell type and circuit modules in the spinal cord.Current opinion in neurobiology · 2019Review
- Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord.Frontiers in molecular neuroscience · 2019Article
- Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.Frontiers in cellular neuroscience · 2019Article
- Loss of Satb2 in the Cortex and Hippocampus Leads to Abnormal Behaviors in Mice.Frontiers in molecular neuroscience · 2019Article
- Sensory and descending motor circuitry during development and injury.Current opinion in neurobiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. Both the cellular components and the molecular mechanisms that instruct the assembly of the spinal sensorimotor system are poorly understood. Here we characterize the connectivity pattern of a sub-population of lamina V inhibitory sensory relay neurons marked during development by the nuclear matrix and DNA binding factor Satb2 (ISR(Satb2)). ISR(Satb2) neurons receive inputs from multiple streams of sensory information and relay their outputs to motor command layers of the spinal cord. Deletion of the Satb2 transcription factor from ISR(Satb2) neurons perturbs their cellular position, molecular profile, and pre- and post-synaptic connectivity. These alterations are accompanied by abnormal limb hyperflexion responses to mechanical and thermal stimuli and during walking. Thus, Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.