Evidence map›Paper›PMID 27477942›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2017

Hyperpolarized

Robert P Thomen, Laura L Walkup, David J Roach, Zackary I Cleveland, John P Clancy, Jason C Woods

Abstract read
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Single-Session Bronchial Thermoplasty Guided byAmerican journal of respiratory and critical care medicine · 2020
    Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Dynamic RBC-To-Membrane Ratio inMagnetic resonance in medicine · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The emerging role of hyperpolarizedExpert review of respiratory medicine · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Robert P ThomenCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Physics, Washington University in St. Louis, St. Louis, MO, United States.
Laura L WalkupCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
David J RoachCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Division of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States.
John P ClancyDivision of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States.
Jason C WoodsCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Physics, Washington University in St. Louis, St. Louis, MO, United States; Division of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States. Electronic address: Jason.woods@cchmc.org.

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
RLDC: Molecular Pathway-Driven Diagnostics & Therapeutics for Rare Lung DiseasesU54HL127672 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2014 to 2018
$3.7M
MR predictors of infection, inflammation, and structural lung damage in CFR01HL116226 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLANCY, JOHN PAUL · 2012 to 2015
$2.1M
NHLBI NIH HHS R01 HL116226NHLBI NIH HHS R01 HL131012NHLBI NIH HHS T32 HL007752NHLBI NIH HHS U54 HL127672
6 · The paper itself

Abstract

backgroundCystic fibrosis (CF) is a genetic disease which carries high morbidity and mortality from lung-function decline. Monitoring disease progression and treatment response in young patients is desirable, but serial imaging via CT is often considered prohibitive, and detailed functional information cannot be obtained using conventional imaging techniques. Hyperpolarized

methods11 healthy controls (age 6-16years) and 11 patients with mild CF (age 8-16years, Forced Expiratory Volume (FEV

resultsFEV

conclusionsHyperpolarized

Indexed as

Cystic FibrosisAdolescentChildDisease ProgressionFemaleForced Expiratory VolumeHumansMagnetic Resonance ImagingMalePredictive Value of TestsPulmonary VentilationRespiratory Function TestsSensitivity and SpecificityXenon IsotopesXenon-129Xenon IsotopesCystic fibrosisHyperpolarizedMriPediatric

Identifiers

PMID27477942
PMCPMC5274600

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.