Evidence map›Paper›PMID 27477855›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016

Molecular characterisation and antifungal susceptibility of clinical Cryptococcus deuterogattii (AFLP6/VGII) isolates from Southern Brazil.

P F Herkert, F Hagen, G L de Oliveira Salvador, R R Gomes, M S Ferreira, V A Vicente, M D Muro, R L Pinheiro, J F Meis, F Queiroz-Telles

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. ExploringJournal of fungi (Basel, Switzerland) · 2022
    Article
  4. Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Review
  5. Review
  6. Journal of fungi (Basel, Switzerland) · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Concurrent infection withExperimental and therapeutic medicine · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. The status of cryptococcosis in Latin America.Memorias do Instituto Oswaldo Cruz · 2018
    Review
  15. Ecoepidemiology of Cryptococcus gattii in Developing Countries.Journal of fungi (Basel, Switzerland) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

P F HerkertPostgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Parana, Curitiba, PR, Brazil.
F HagenDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands. f.hagen@cwz.nl.ORCID http://orcid.org/0000-0002-5622-1916
G L de Oliveira SalvadorDepartment of Internal Medicine, Federal University of Parana, Curitiba, PR, Brazil.
R R GomesPostgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Parana, Curitiba, PR, Brazil.
M S FerreiraFederal University of Uberlandia, Uberlândia, MG, Brazil.
V A VicentePostgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Parana, Curitiba, PR, Brazil.
M D MuroLaboratory of Mycology, Hospital de Clínicas, Federal University of Parana, Curitiba, PR, Brazil.
R L PinheiroLaboratory of Mycology, Hospital de Clínicas, Federal University of Parana, Curitiba, PR, Brazil.
J F MeisDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.
F Queiroz-TellesCommunitarian Health Department, Hospital de Clínicas, Federal University of Parana, Curitiba, PR, Brazil.
Hospital de Clínicas Universidade Federal do Paraná · BRCanisius-Wilhelmina Ziekenhuis · NLNational Council for Scientific and Technological Development · BRRadboud University Nijmegen · NLUniversidade Estadual do Paraná · BRUniversidade Federal de Uberlândia · BRUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcosis, caused by Cryptococcus gattii sensu lato, is an emerging disease that was initially found in (sub)tropical regions but recently expanded to temperate regions. Cryptococcus gattii s.l. infections are mostly encountered in healthy individuals, frequently affecting both lungs and the central nervous system (CNS). Usually, C. gattii s.l. is less susceptible to antifungal compounds than its counterpart, C. neoformans s.l. We studied 18 clinical C. gattii s.l. isolates with amplified fragment length polymorphism (AFLP) fingerprinting, mating-typing, multi-locus sequence typing (MLST) and antifungal susceptibility testing. All isolates were C. deuterogattii (genotype AFLP6/VGII), 14 were mating-type α and four were type a. Amphotericin B, itraconazole, voriconazole, posaconazole and isavuconazole showed high activity, with minimum inhibitory concentration (MIC) ranges of 0.063-0.25, 0.031-0.25, 0.031-0.25, 0.031-0.25 and <0.016-0.25 μg mL

Indexed as

Drug Resistance, FungalAmplified Fragment Length Polymorphism AnalysisAntifungal AgentsBrazilCryptococcosisCryptococcus gattiiDNA FingerprintingFemaleGenes, Mating Type, FungalGenotypeHumansMaleMicrobial Sensitivity TestsMultilocus Sequence TypingAntifungal Agents

Identifiers

PMID27477855
OpenAlexW2489528720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.