ReviewMolecular endocrinology (Baltimore, Md.)2016
Minireview: Endocrine Disruptors: Past Lessons and Future Directions.
Abstract readReview
In one paragraph
Review in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of the endocrine disrupting properties of bisphenol AF: a case study applying the European regulatory criteria and guidance.Environmental health : a global access science source · 2021Pooled it
- Associations ofBiomolecules · 2026Article
- Combined Exposure to Endocrine Disruptors, BPA and BP-3, during Pregnancy and Lactation Alters Postnatal Body Mass, Growth, White Adipose Tissue Morphology, and Adipogenic Gene Expression in a Sex-Specific Manner.Environment & health (Washington, D.C.) · 2026Article
- Studying endocrine disrupting chemicals from molecular targets to mixture model approach: lessons from the thyroid model.The Journal of clinical endocrinology and metabolism · 2026Review
- Glyphosate exposure and hormonal disruption in pregnancy: evidence from a birth cohort in Puerto Rico.Journal of exposure science & environmental epidemiology · 2026Article
- Selection for Function in Early Life: Implications for Early-Onset Pathologies.Evolutionary applications · 2026Article
- P.A.D.D.L.E.: a hypothesis generation tool for assessing pollution's potential role in disease.Scientific reports · 2026Article
- Molecular Mechanisms of EDC-Induced Alzheimer's Disease and of Traditional Chinese Medicine Active Substances in Treating AD and Antagonizing EDC-Induced Effects.Neurochemical research · 2025Article
- Innovative eco-sustainable reishi mushroom-based adsorbents for progesterone removal and agricultural sustainability.RSC advances · 2025Article
- Associations Between Daily-Use Products and Urinary Biomarkers of Endocrine-Disrupting Chemicals in Adults of Reproductive Age.International journal of environmental research and public health · 2025Article
- Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure.Current nutrition reports · 2025Review
- Exploring the Mechanisms of EDCs-Induced Metabolic Disorders in Humans Using Network Toxicology and Molecular Docking.NAM journal · 2025Article
- Global research on endocrine disruptors as emerging hazards for human health and the environment.Frontiers in endocrinology · 2025Review
- Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature.International journal of molecular sciences · 2024Review
- Effects of Environmental Enrichment on Exposure to Human-Relevant Mixtures of Endocrine Disrupting Chemicals in Zebrafish.Animals : an open access journal from MDPI · 2024Article
- Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies.Diabetology & metabolic syndrome · 2024Review
- The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses.Frontiers in immunology · 2024Review
- Responses of multifunctional immune complement component 1q (C1q) and apoptosis-related genes in Macrophthalmus japonicus tissues and human cells following exposure to environmental pollutants.Cell stress & chaperones · 2023Article
- Evaluation of flaxseed lignan-enriched extract targeting autophagy, apoptosis, and hedgehog pathways against experimentally induced obesity.Journal of advanced veterinary and animal research · 2023Article
- Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review ofJournal of advanced veterinary and animal research · 2023Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Thaddeus T SchugNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Anne F JohnsonNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Linda S BirnbaumNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Theo ColbornNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Louis J GuilletteNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
David P CrewsNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Terry CollinsNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Ana M SotoNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Frederick S Vom SaalNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
John A McLachlanNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Carlos SonnenscheinNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Jerrold J HeindelNational Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Funding
Mechanisms of developmental toxicity of Bisphenol-AR01ES008314 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 1996 to 2016
$6.8MStudies of the fate of environmental contaminants in humans and animalsZIABC011476 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BIRNBAUM, LINDA · 2013 to 2019
$5.8MAncestral Exposures/Modern Responses to EDCsR01ES023254 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI CREWS, DAVID P, GORE, ANDREA C · 2013 to 2017
$1.9MSexually dimorphic effects of endocrine disruptors on brain & behaviorR01ES020662 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI CREWS, DAVID P, GORE, ANDREA C · 2011 to 2015
$1.8MSexually dimorphic effects of endocrine disruptors on brain and behaviorR56ES020662 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI CREWS, DAVID P, GORE, ANDREA C · 2017 to 2017
$297kNIEHS NIH HHS R01 ES008314NIEHS NIH HHS R01 ES020662NIEHS NIH HHS R01 ES023254NIEHS NIH HHS R56 ES020662
Abstract
Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue, debate, and concern among scientists, physicians, regulators, and the public. The emergence and development of this field of study has not always followed a smooth path, and researchers continue to wrestle with questions about the low-dose effects and nonmonotonic dose responses seen with EDCs, their biological mechanisms of action, the true pervasiveness of these chemicals in our environment and in our bodies, and the extent of their effects on human and wildlife health. This review chronicles the development of the unique, multidisciplinary field of endocrine disruption, highlighting what we have learned about the threat of EDCs and lessons that could be relevant to other fields. It also offers perspectives on the future of the field and opportunities to better protect human health.
Indexed as
AnimalsBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsEpigenesis, GeneticHormonesHumansPhenolsReproductionSignal TransductionBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsHormonesPhenols
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