Evidence map›Paper›PMID 27477585›Full record

ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2016

Artifactual mutations resulting from DNA lesions limit detection levels in ultrasensitive sequencing applications.

Barbara Arbeithuber, Kateryna D Makova, Irene Tiemann-Boege

Open access · goldAbstract read
In one paragraph

Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Long-read sequencing for neurological disorders: opportunities, challenges, and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  5. De novo rates of aProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  7. Article
  8. Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Barbara ArbeithuberInstitute of Biophysics, Johannes Kepler University, Linz 4020, Austria.
Kateryna D MakovaDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.
Irene Tiemann-BoegeInstitute of Biophysics, Johannes Kepler University, Linz 4020, Austria irene.tiemann@jku.at.
Pennsylvania State University · USJohannes Kepler University of Linz · AT

Funding

The Dynamics of Mitochondrial MutationsR01GM116044 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAKOVA, KATERYNA, NIELSEN, RASMUS · 2015 to 2018
$2.4M
NIGMS NIH HHS R01 GM116044
6 · The paper itself

Abstract

The need in cancer research or evolutionary biology to detect rare mutations or variants present at very low frequencies (<10

Indexed as

ArtifactsMutationDNAHigh-Throughput Nucleotide SequencingHumansMaleSensitivity and SpecificitySequence Analysis, DNADNAartifactual mutationsDNA lesionsPCR jackpotsequencing errorsultrasensitive detection

Identifiers

PMID27477585
PMCPMC5144678
OpenAlexW2483603339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.