ReviewNeuroscience and biobehavioral reviews2016
The role of experience in adolescent cognitive development: Integration of executive, memory, and mesolimbic systems.
Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- The Effect of Pubertal Status on Self-Regulation of Behavior and Executive Functions-A Systematic Review.Developmental psychobiology · 2025Pooled it
- Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.JAMA psychiatry · 2021Pooled it
- Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies.Frontiers in public health · 2019Pooled it
- A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation.Child development · 2019Trial
- Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD.NeuroImage · 2019Trial
- Neural Sensitivity to Social Media Use: Implications for Sleep Duration in Adolescents.Journal of sleep research · 2026Article
- Neural focalization of dorsolateral prefrontal cortex and the inferior parietal lobule is associated with inhibitory control performance in adolescence.Developmental cognitive neuroscience · 2026Article
- Increasing representational capacity in the hippocampal-frontoparietal system underlies hierarchical development of temporal memory.Developmental cognitive neuroscience · 2026Review
- Hippocampal representations of temporal structure increase in scale and symmetry across development.bioRxiv : the preprint server for biology · 2026Article
- Article
- Alexithymia and non-suicidal self-ınjury in adolescents: the roles of emotion dysregulation, impulsivity, and self-esteem.BMC psychiatry · 2026Article
- Related memories exhibit interference during learning in adults but later retrieval in children.PloS one · 2026Article
- Review
- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Article
- HKD-MGIN: a physics informed graph neural network using heat kernel diffusion for mapping adolescent functional brain connectivity.Machine learning for computational science and engineering · 2025Article
- Associations between social media and crystallized and fluid performance trajectories in early adolescence.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Article
- The role of negative life events and parental mental health in adolescent self-regulation: insights from the longitudinal ABCD study.Child and adolescent psychiatry and mental health · 2025Article
- Linking the Supplementary Motor Network and Executive Function in Developing Brain.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adolescence marks a time of unique neurocognitive development, in which executive functions reach adult levels of maturation. While many core facets of executive function may reach maturation in childhood, these processes continue to be refined and stabilized during adolescence. We propose that this is mediated, in part, by interactions between the hippocampus and prefrontal cortex. Specifically, we propose that development of this circuit refines adolescents' ability to extract relevant information from prior experience to support task-relevant behavior. In support of this model, we review evidence for protracted structural and functional development both within and across the hippocampus and prefrontal cortex. We describe emerging research demonstrating the refinement of adolescents' ability to integrate prior experiences to support goal-oriented behavior, which parallel hippocampal-prefrontal integration. Finally, we speculate that the development of this circuit is mediated by increases in dopaminergic neuromodulation present in adolescence, which may underlie memory processing, plasticity, and circuit integration. This model provides a novel characterization of how memory and executive systems integrate throughout adolescence to support adaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.