ArticleCell reports2016
Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Transcriptomic analysis of spinal V1 interneurons informs their multifunctional role in motor output.Nature communications · 2026Article
- Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a neurons.Nature communications · 2026Article
- Regeneration after Spinal Cord Injury: A Review on the Crucial Aspects of V2a Interneurons.Journal of neurotrauma · 2026Article
- The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons.Nucleic acids research · 2025Article
- The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output.bioRxiv : the preprint server for biology · 2024Article
- Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development.Cell & bioscience · 2024Article
- Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.Cellular and molecular life sciences : CMLS · 2024Article
- V2a neurons restore diaphragm function in mice following spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development.Frontiers in cellular neuroscience · 2024Article
- Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.Nature communications · 2023Article
- Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells.Neural development · 2023Article
- Chx10+V2a interneurons in spinal motor regulation and spinal cord injury.Neural regeneration research · 2023Review
- Functional analysis of the Vsx2 super-enhancer uncovers distinct cis-regulatory circuits controlling Vsx2 expression during retinogenesis.Development (Cambridge, England) · 2022Article
- Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro.Stem cell reports · 2022Article
- The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.Nature communications · 2022Article
- Integration of Spatial and Temporal Patterning in the Invertebrate and Vertebrate Nervous System.Frontiers in neuroscience · 2022Review
- Restoring Sensorimotor Function Through Neuromodulation After Spinal Cord Injury: Progress and Remaining Challenges.Frontiers in neuroscience · 2021Review
- Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.Frontiers in cell and developmental biology · 2021Article
- Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.Cellular and molecular life sciences : CMLS · 2020Article
- PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway.Cell reports · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
During development, two cell types born from closely related progenitor pools often express identical transcriptional regulators despite their completely distinct characteristics. This phenomenon implies the need for a mechanism that operates to segregate the identities of the two cell types throughout differentiation after initial fate commitment. To understand this mechanism, we investigated the fate specification of spinal V2a interneurons, which share important developmental genes with motor neurons (MNs). We demonstrate that the paired homeodomain factor Chx10 functions as a critical determinant for V2a fate and is required to consolidate V2a identity in postmitotic neurons. Chx10 actively promotes V2a fate, downstream of the LIM-homeodomain factor Lhx3, while concomitantly suppressing the MN developmental program by preventing the MN-specific transcription complex from binding and activating MN genes. This dual activity enables Chx10 to effectively separate the V2a and MN pathways. Our study uncovers a widely applicable gene regulatory principle for segregating related cell fates.
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