ReviewTrends in neurosciences2016
Social Preference and Glutamatergic Dysfunction: Underappreciated Prerequisites for Social Dysfunction in Schizophrenia.
Review in Trends in neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization.Frontiers in molecular neuroscience · 2022Pooled it
- Effects of NMDA-receptor blockade by ketamine on mentalizing and its neural correlates in humans: a randomized control trial.Scientific reports · 2023Trial
- Prefrontal cortex to dorsal medial striatum neural circuitry mediates social interaction.Zoological research · 2026Article
- Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System.Neuroscience bulletin · 2026Review
- Implicit neural sensitivity for negatively valued social and non-social visual scenes in young adults exposed to childhood adversity.Psychological medicine · 2025Article
- Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.Animal models and experimental medicine · 2024Article
- Article
- Aberrant Effective Connectivity During Eye Gaze Processing Is Linked to Social Functioning and Symptoms in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Social Motivation in Schizophrenia: What's Effort Got to Do With It?Schizophrenia bulletin · 2023Review
- Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.Brain : a journal of neurology · 2022Article
- Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study.Translational psychiatry · 2021Article
- Dynamic causal modeling of eye gaze processing in schizophrenia.Schizophrenia research · 2021Article
- People with schizophrenia do not show the normal benefits of social versus nonsocial attentional cues.Neuropsychology · 2020Article
- Experimental approaches to social disconnection in the general community: can we learn from schizophrenia research?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Social Cognition and Schizophrenia: Unresolved Issues and New Challenges in a Maturing Field of Research.Schizophrenia bulletin · 2020Article
- From Social Cognition to Negative Symptoms in Schizophrenia: How Do We Get There From Here?Schizophrenia bulletin · 2020Article
- Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.The EMBO journal · 2020Article
- Effects of post-weaning social isolation on social behaviors and oxytocinergic activity in male and female rats.Heliyon · 2019Article
- Reduced Neural Sensitivity to Social vs Nonsocial Reward in Schizophrenia.Schizophrenia bulletin · 2019Article
- Understanding the Association Between Negative Symptoms and Performance on Effort-Based Decision-Making Tasks: The Importance of Defeatist Performance Beliefs.Schizophrenia bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Impaired social functioning is pervasive in schizophrenia. Unfortunately, existing treatments have limited efficacy, and possible psychological or neurobiological mechanisms underlying social dysfunction in this disorder remain obscure. Here, we evaluate whether social preference, one key aspect of social processing that has been largely overlooked in schizophrenia research, and N-methyl-d-aspartate receptor (NMDAR) dysfunction can provide insights into the mechanism underlying social dysfunction in schizophrenia. Based on evidence from developmental psychology, and behavioral and clinical neuroscience, we propose a heuristic model in which reduced NMDAR function may induce disrupted social preference that can subsequently lead to social cognitive impairment and social disability. We discuss its implications in terms of the pathophysiology of schizophrenia, other disorders with marked social disability, and potential treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.