Evidence map›Paper›PMID 27477127›Full record

ReviewNature reviews. Immunology2016

Regulation of pattern recognition receptor signalling in plants.

Daniel Couto, Cyril Zipfel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 615 papers.

0numbers the graph read from it
0cells of the map it votes in
615citing papers in PubMed
217.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

615 citing papers in PubMed, 1,378 citations in OpenAlex.

  1. Review
  2. Effects of Atmospheric COPlant, cell & environment · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Discovering common and population-specific QTLs for leaf rust resistance in different Barley populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. PlantInternational journal of molecular sciences · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

555 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daniel CoutoThe Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK.
Cyril ZipfelThe Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK.
Norwich Research Park · GBSainsbury Laboratory · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Recognition of pathogen-derived molecules by pattern recognition receptors (PRRs) is a common feature of both animal and plant innate immune systems. In plants, PRR signalling is initiated at the cell surface by kinase complexes, resulting in the activation of immune responses that ward off microorganisms. However, the activation and amplitude of innate immune responses must be tightly controlled. In this Review, we summarize our knowledge of the early signalling events that follow PRR activation and describe the mechanisms that fine-tune immune signalling to maintain immune homeostasis. We also illustrate the mechanisms used by pathogens to inhibit innate immune signalling and discuss how the innate ability of plant cells to monitor the integrity of key immune components can lead to autoimmune phenotypes following genetic or pathogen-induced perturbations of these components.

Indexed as

Immunity, InnatePlant ImmunityPlantsReceptors, Pattern RecognitionSignal TransductionReceptors, Pattern Recognition

Identifiers

PMID27477127
OpenAlexW2479540212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.