ReviewMovement disorders : official journal of the Movement Disorder Society2016
The best medicine? The influence of physical activity and inactivity on Parkinson's disease.
Review in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517371 (Walking and mHealth to Increase Participation in Parkinson Disease), which is not on this map. Cited by 60 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Walking and mHealth to Increase Participation in Parkinson Disease
Who cites it
60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Unsupervised Functional Capacity Testing at Home: A Systematic Review.Sports medicine - open · 2026Pooled it
- Systematic review for the prevention and management of falls and fear of falling in patients with Parkinson's disease.Brain and behavior · 2022Pooled it
- Effects of non-invasive brain stimulation on walking and balance ability in Parkinson's patients: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Gait parameters of Parkinson's disease compared with healthy controls: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Association of Levels of Physical Activity With Risk of Parkinson Disease: A Systematic Review and Meta-analysis.JAMA network open · 2018Pooled it
- Vascular Risk Factors and the Risk of Incident Parkinson's Disease Among Stroke Survivors: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2026Article
- Voluntary exercise increases striatal dopamine release and improves motor performance in aging mice.NPJ Parkinson's disease · 2025Article
- Daily steps are a predictor of, but perhaps not a risk factor for Parkinson's disease: findings from the UK Biobank.NPJ Parkinson's disease · 2025Article
- Depending on intensity, exercise improved or worsened pathology in a model of prodromal Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Influence of Exercise on Oxygen Consumption, Pulmonary Ventilation, and Blood Gas Analyses in Individuals with Chronic Diseases.Life (Basel, Switzerland) · 2025Review
- Identifying Barriers and Facilitators to Accessing Care for Historically Marginalized Communities Affected by Parkinson Disease: A Qualitative Study.Journal of racial and ethnic health disparities · 2025Article
- Global, regional and national temporal trends in Parkinson's disease incidence, disability-adjusted life year rates in middle-aged and older adults: a cross-national inequality analysis and Bayesian age-period-cohort analysis based on the global burden of disease 2021.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Sex and gender differences in the molecular etiology of Parkinson's disease: considerations for study design and data analysis.Biology of sex differences · 2025Review
- Walking reduces the risk of dementia in patients with Parkinson's disease: a longitudinal follow-up study.Therapeutic advances in neurological disorders · 2025Article
- The IntegraPark Study: An Opportunity to Facilitate High-Intensity Exercise with Immersive Virtual Reality in Parkinson's Disease Patients.Journal of functional morphology and kinesiology · 2024Article
- Measuring Physical Functioning Using Wearable Sensors in Parkinson Disease and Chronic Obstructive Pulmonary Disease (the Accuracy of Digital Assessment of Performance Trial Study): Protocol for a Prospective Observational Study.JMIR research protocols · 2024Article
- Physical activity and sleep pattern in relation to incident Parkinson's disease: a cohort study.The international journal of behavioral nutrition and physical activity · 2024Article
- Motor dysfunction in Parkinson's patients: depression differences in a latent growth model.Frontiers in aging neuroscience · 2024Article
- Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson's disease.NPJ digital medicine · 2023Article
- Muscle strength and spatiotemporal gait parameters in people with Parkinson´s disease. A pilot study.Revista de neurologia · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The incidence of Parkinson's disease (PD) is expected to increase as our population ages and will likely strain the projected capacity of our health care system. Despite being the most common movement disorder, there have been few noninvasive therapeutic advances for people with PD since the first levodopa clinical trial in 1961. The study of PD pathogenesis, combined with an appreciation for the biochemical mechanisms by which physical activity and exercise may impact physiology, has resulted in emerging hypotheses for new modifiable risk factors for PD. Physical activity and exercise as a means of preventing PD, or maintaining the functionality of people with PD, are a promising area of investigation. Conversely, physical inactivity is implicated in many disease states, some of which are also correlated with the development of PD, such as metabolic syndrome. The primary relationship between these diseases is likely rooted in heightened inflammation and oxidative stress at the cellular level. Physical activity and exercise as a means of attenuating inflammation have led to increased interest in related potential therapeutic targets for PD. Ultimately, these findings may translate into low-cost, universally available therapies for PD disease modification or prevention. © 2016 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.