Evidence map›Paper›PMID 27477017›Full record

ReviewNeuron2016

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits.

Robin Tremblay, Soohyun Lee, Bernardo Rudy

Abstract readReview
In one paragraph

Review in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,207 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,207citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,207 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Neuromodulation of the central nervous system for facial pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Pooled it
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  3. Review
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  7. Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026
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1,147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robin TremblayDepartment of Neuroscience and Physiology, Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA.
Soohyun LeeDepartment of Neuroscience and Physiology, Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA.
Bernardo RudyDepartment of Neuroscience and Physiology, Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA; Department of Anesthesiology, Preoperative Care, and Pain Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: bernardo.rudy@nyumc.org.

Funding

The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MACHOLD, ROBERT P · 2012 to 2023
$15.5M
Circuit mechanisms underlying cortical communicationsZIAMH002959 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEE, SOOHYUN · 2017 to 2025
$13.7M
EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN THE CNSR01NS030989 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 1992 to 2015
$6.3M
Molecular Components of A-type K+ ChannelsR01NS045217 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2003 to 2013
$4.6M
Functional diversity of cholinergic streams modulating cognitionR21NS093987 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2015 to 2016
$466k
NINDS NIH HHS P01 NS074972NINDS NIH HHS R01 NS030989NINDS NIH HHS R01 NS045217NINDS NIH HHS R21 NS093987
6 · The paper itself

Abstract

Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population, GABAergic interneurons are highly heterogeneous, forming functional classes based on their morphological, electrophysiological, and molecular features, as well as connectivity and in vivo patterns of activity. Here we review our current understanding of neocortical interneuron diversity and the properties that distinguish cell types. We then discuss how the involvement of multiple cell types, each with a specific set of cellular properties, plays a crucial role in diversifying and increasing the computational power of a relatively small number of simple circuit motifs forming cortical networks. We illustrate how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.

Indexed as

AnimalsCell Differentiationgamma-Aminobutyric AcidHumansInterneuronsNeocortexNerve NetNeural Inhibitiongamma-Aminobutyric Acid

Identifiers

PMID27477017
PMCPMC4980915

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.