Evidence map›Paper›PMID 27477016›Full record

ReviewNeuron2016

Analysis of Neuronal Spike Trains, Deconstructed.

Johnatan Aljadeff, Benjamin J Lansdell, Adrienne L Fairhall, David Kleinfeld

Abstract readReview
In one paragraph

Review in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Review
  3. Structural dynamics and neural representation of wing deformation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Inferring neural population codes forProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Identification of movie encoding neurons enables movie recognition AI.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Visual neurons recognize complex image transformations.bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Johnatan AljadeffDepartment of Physics, University of California, San Diego, San Diego, CA 92093, USA; Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA. Electronic address: aljadeff@uchicago.edu.
Benjamin J LansdellDepartment of Applied Mathematics, University of Washington, Seattle, WA 98195, USA.
Adrienne L FairhallDepartment of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA; WRF UW Institute for Neuroengineering, University of Washington, Seattle, WA 98195, USA.
David KleinfeldDepartment of Physics, University of California, San Diego, San Diego, CA 92093, USA; Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: dk@physics.ucsd.edu.

Funding

Supplement request to: Revealing the connectivity and functionality of brain stem circuitsU01NS090595 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESCHENES, MARTIN, FREUND, YOAV SHAI · 2014 to 2016
$2.6M
Sensorimotor Loops in Vibrissa SomatosensationR01NS058668 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2007 to 2016
$2.4M
NINDS NIH HHS R01 NS058668NINDS NIH HHS U01 NS090595
6 · The paper itself

Abstract

As information flows through the brain, neuronal firing progresses from encoding the world as sensed by the animal to driving the motor output of subsequent behavior. One of the more tractable goals of quantitative neuroscience is to develop predictive models that relate the sensory or motor streams with neuronal firing. Here we review and contrast analytical tools used to accomplish this task. We focus on classes of models in which the external variable is compared with one or more feature vectors to extract a low-dimensional representation, the history of spiking and other variables are potentially incorporated, and these factors are nonlinearly transformed to predict the occurrences of spikes. We illustrate these techniques in application to datasets of different degrees of complexity. In particular, we address the fitting of models in the presence of strong correlations in the external variable, as occurs in natural sensory stimuli and in movement. Spectral correlation between predicted and measured spike trains is introduced to contrast the relative success of different methods.

Indexed as

AlgorithmsModels, NeurologicalAction PotentialsAnimalsBrainHumansNeuronsTime Factorsdimensional reductionfeature vectorneuroinformaticspredictive modelingreverse correlationsystems identificationtime series

Identifiers

PMID27477016
PMCPMC4970242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.