ArticleeLife2016
Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Reflections on Model Species in Evolutionary Developmental Biology.Results and problems in cell differentiation · 2026Review
- Repeated evolution of similar phenotypes: Integrating comparative methods with developmental pathways.Genetics and molecular biology · 2023Article
- Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken.Development (Cambridge, England) · 2022Article
- Sequential inGenes & development · 2021Article
- Limb positioning and initiation: An evolutionary context of pattern and formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Chromatin topology and the timing of enhancer function at theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Megaevolutionary dynamics and the timing of evolutionary innovation in reptiles.Nature communications · 2020Article
- Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation.Molecular cell · 2019Article
- Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution.Nature communications · 2018Article
- Similarities and differences in the regulation of HoxD genes during chick and mouse limb development.PLoS biology · 2018Article
- Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids.Nature · 2018Article
- Forces driving the three-dimensional folding of eukaryotic genomes.Molecular systems biology · 2018Review
- Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.PLoS genetics · 2018Article
- Appendages and gene regulatory networks: Lessons from the limbless.Genesis (New York, N.Y. : 2000) · 2018Review
- TheGenes & development · 2017Article
- Limb development: a paradigm of gene regulation.Nature reviews. Genetics · 2017Review
- Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within land vertebrate species, snakes display extreme variations in their body plan, characterized by the absence of limbs and an elongated morphology. Such a particular interpretation of the basic vertebrate body architecture has often been associated with changes in the function or regulation of Hox genes. Here, we use an interspecies comparative approach to investigate different regulatory aspects at the snake HoxD locus. We report that, unlike in other vertebrates, snake mesoderm-specific enhancers are mostly located within the HoxD cluster itself rather than outside. In addition, despite both the absence of limbs and an altered Hoxd gene regulation in external genitalia, the limb-associated bimodal HoxD chromatin structure is maintained at the snake locus. Finally, we show that snake and mouse orthologous enhancer sequences can display distinct expression specificities. These results show that vertebrate morphological evolution likely involved extensive reorganisation at Hox loci, yet within a generally conserved regulatory framework.
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Registered trials
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