Evidence map›Paper›PMID 27476533›Full record

ArticleChemical communications (Cambridge, England)2016

Endocrine-specific NIR fluorophores for adrenal gland targeting.

Yoshitomo Ashitate, Andrew Levitz, Min Ho Park, Hoon Hyun, Vivek Venugopal, GwangLi Park, Georges El Fakhri, Maged Henary, Sylvain Gioux, John V Frangioni and 1 more

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  7. Near-Infrared Contrast Agents for Bone-Targeted Imaging.Tissue engineering and regenerative medicine · 2019
    Review
  8. Real-Time Fluorescence Imaging in Thoracic Surgery.The Korean journal of thoracic and cardiovascular surgery · 2019
    Article
  9. Article
  10. Introduction of various substitutions to the methine bridge of heptamethine cyanine dyes Via substituted dianil linkers.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2018
    Article
  11. Article
  12. Review
  13. Fluorescence-Guided Surgery.Frontiers in oncology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoshitomo AshitateDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Andrew LevitzDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. mhenary1@gsu.edu.
Min Ho ParkDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Surgery, Chonnam National University Medical School, Gwangju 501-746, South Korea.
Hoon HyunDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-746, South Korea.
Vivek VenugopalDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
GwangLi ParkDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.
Georges El FakhriGordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.
Maged HenaryDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. mhenary1@gsu.edu.
Sylvain GiouxDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and ICube Laboratory, University of Strasbourg, Illkirch cedex 67412, France.
John V FrangioniDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Curadel, LLC, 377 Plantation Street, Worcester, MA 01605, USA.
Hak Soo ChoiDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.

Funding

Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided SurgerR01EB010022 · NIBIB · CURADEL, LLC · PI FRANGIONI, JOHN V · 2010 to 2013
$2.8M
Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability RetentionR01EB017699 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI NORMANDIN, MARC DAVID · 2014 to 2017
$1.6M
Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDIK01DK093603 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GIOUX, SYLVAIN · 2012 to 2015
$518k
NIBIB NIH HHS R01 EB010022NIBIB NIH HHS R01 EB011523NIBIB NIH HHS R01 EB017699NIDDK NIH HHS K01 DK093603
6 · The paper itself

Abstract

The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.

Indexed as

Adrenal GlandsFluorescent DyesHumansInfrared RaysInjections, IntravenousSurgery, Computer-AssistedFluorescent Dyes

Identifiers

PMID27476533
PMCPMC4982771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.